ioSensory Neurons: Human iPSC-Derived Neurons for Reliable Pain Research

One of the biggest challenges in pain research is the lack of a physiologically relevant in vitro cell models with consistent nociceptor marker expression and functionality. 

ioSensory Neurons are built to address this challenge. They are a highly pure, easy to use and functional human iPSC-derived nociceptor model. As the cells are precision reprogrammed with opti-ox™ technology, ioSensory Neurons have consistency built-in and always express the same key markers regardless of lot or vial. Such consistency, combined with an unprecedented over 99% purity, a validated functional nociceptor phenotype and a simple protocol will help chronic pain researchers to improve the reliability and reproducibility of their experiments.

Within 7 days post-revival, ioSensory Neurons form a highly pure sensory neuronal population with a defined nociceptor identity, characterised by the expression of the pan-sensory neuron markers, PRPH, BRN3A, ISL1 and TUBB3, and key markers of nociceptors, NTRK1 and TRPV1. These cells also display spontaneous activity and show a functional nociceptor phenotype, as demonstrated by responsiveness to noxious stimuli against TRPV1, TRPM3, and TRPM8.

Don’t settle for non-human in vitro models or long, complex iPSC differentiation protocols that lead to inconsistent results. Start running reliable nociception assays with ioSensory Neurons today.

ioSensory Neurons are now available under an early access program. Fill out the form to speak to an expert about ioSensory Neurons.