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Natural killer (NK) cells are immune cells capable of killing target cells and can be genetically modified to express chimeric antigen receptors (CARs). CAR NK-cell therapy is an innovative type of cancer immunotherapy for solid tumors and hematological malignancies.
Functionally, CAR-NK cells kill target cancer cells in a CAR-dependent manner. Compared to traditional CAR-T cells, CAR-NK cells and unmodified NK cells offer safety advantages. The limited lifespan of CAR-NK cells greatly lowers the risk of on-target/off-tumor toxicity to normal cells. Additionally, reduced risk for alloreactivity and Graft versus host disease (GvHD) allows CAR-NK cells to be generated from a variety of sources, including NK92 cells, peripheral blood mononuclear cells (PBMCs), umbilical cord blood (UCB), and induced pluripotent stem cells (iPSCs).
Sino Biological is an international reagent supplier and contract research service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced with a stringent quality management system, and include unique bioreagents addressing areas such as cell therapy, stem cell, and infectious disease research. For example, Sino Biological has a wealth of viral antigens (Provir®) and corresponding antibodies, with one of the world’s Extensive collections. Sino Biological is also a well-recognized, qualified source of recombinant cytokines and high-quality GMP-grade cytokines. In addition, Sino Biological offers contract research production services for the custom development of full length, bioactive proteins and high-affinity antibodies, along with other services. To learn more about Sino Biological visit www.sinobiological.com, follow us on LinkedIn or @SinoInc on Twitter.
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