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Therapeutic Targets in CAR NK-Cell Therapy

Therapeutic Targets in CAR NK-Cell Therapy


Natural killer (NK) cells are immune cells capable of killing target cells and can be genetically modified to express chimeric antigen receptors (CARs). CAR NK-cell therapy is an innovative type of cancer immunotherapy for solid tumors and hematological malignancies.


Functionally, CAR-NK cells kill target cancer cells in a CAR-dependent manner. Compared to traditional CAR-T cells, CAR-NK cells and unmodified NK cells offer safety advantages. The limited lifespan of CAR-NK cells greatly lowers the risk of on-target/off-tumor toxicity to normal cells. Additionally, reduced risk for alloreactivity and Graft versus host disease (GvHD) allows CAR-NK cells to be generated from a variety of sources, including NK92 cells, peripheral blood mononuclear cells (PBMCs), umbilical cord blood (UCB), and induced pluripotent stem cells (iPSCs).


Sino Biological provides a variety of CAR-NK-related proteins and antibodies with superior quality.



About Sino Biological
Sino Biological is an international reagent supplier and service provider. The company specializes in recombinant protein production and antibody development. All of Sino Biological's products are independently developed and produced, including recombinant proteins, antibodies and cDNA clones. Sino Biological is the researchers' one-stop technical services shop for the advanced technology platforms they need to make advancements. In addition, Sino Biological offers pharmaceutical companies and biotechnology firms pre-clinical production technology services for hundreds of monoclonal antibody drug candidates