Twist Oligo Pools for High-Throughput Screens

Oligo pools are utilized in many applications including generation of CRISPR guide RNA (sgRNA) libraries, peptide and protein screens, and high-throughput reporter assays. Accuracy and uniformity of oligo synthesis are critical to ensure high quality oligo libraries are built and screens are precisely targeted.

Twist Oligo Pools are highly diverse collections of single-stranded oligonucleotides synthesized using our silicon-based DNA writing technology. Our synthesis platform enables massively parallel production of hundreds of thousands of high-quality, accurate oligos per run, allowing the generation of complex and diverse CRISPR screening sgRNA libraries for precision gene editing and maximized screening efficiency.

Due to the sheer scale of our DNA synthesis capability, there are virtually no limitations to the number of unique oligos that can be assembled into a pool. Don't restrict the outcome of your application—order Oligo Pools tailored precisely to your experiment.