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CRISPR and Genome Editing – News and Features

Double helix structure of DNA.

Novel Protein Found To Inhibit Activity of CRISPR-Cas System

Researchers discovered novel anti-CRISPR protein called AcrIF25, which inhibits the activity of the CRISPR-Cas system by dismantling the I-F type CRISPR-Cas complex (Csy complex), providing a new approach for precise control of the CRISPR-Cas system.
Stands of DNA with green coding overlay.

Genome Recording Strategy Enables Cells To Keep a History of Past Events

A new genome recording strategy aims to turn cells into their own historians, by storing information about transient biological events inside living cells.
Illustration of hands using tweezers and scissors to edit DNA.

Novel CRISPR Method Teaches Gene Scissors To Detect RNA

CRISPR-Cas systems have become a plentiful source of technologies for molecular diagnostics and researchers have now developed a novel method that enables the detection of RNA with Cas12 nucleases, which naturally target DNA.
Cancer cells.

Antiviral Protein Acts Both as an Ally and an Enemy in Cancer Treatment

Investigators have uncovered new details about the role of a protein called interferon regulatory factor (IRF1) in cancer progression and treatment response, offering new insight that can potentially help improve the effectiveness of cancer immunotherapy.

Researchers Discover Fat Cell Receptor Involved in Regulating Metabolic Health

Excess PAQR4 leads to a buildup of ceramides that prompts green-labeled fat cells to lose their lipids and identity, resulting in the accumulation of undifferentiated and dysfunctional cells.
Above image shows a metastatic tumor in the left lung of a patient and the bottom image shows no tumor following treatment.

Immunotherapy Approach May Be Effective for Some Metastatic Tumors

Early findings from a small clinical trial provide evidence that a new cellular immunotherapy approach may effectively treat metastatic solid tumors.
 A DNA double helix being "edited" with a pair of tweezers.

Novel Genome Editing Approach Restores Hearing in Mouse Model of Inherited Deafness

Researchers have successfully restored hearing in a mouse model of inherited deafness using a novel in vivo gene editing approach.
Plastic model of the lungs.

Prime Editing Corrects Cystic Fibrosis-Causing Mutation in Lung Cells

Researchers have developed a gene-editing approach that efficiently corrects the most common mutation that causes cystic fibrosis. With further development, it could pave the way for treatments that are administered only once and have fewer side effects.
Two cytotoxic T cells attack a cancer cell.

Stem Cell-Derived Therapy Shows Early Promise for Resistant Liver Cancer

An innovative new stem cell-derived therapy could be used to better target and treat the most common form of liver cancer.
A person undergoing intravenous therapy

Potential Therapeutic Target Could Boost Pancreatic Cancer Chemotherapy and Reduce Spread

A research team has discovered that nidogen-2 reduces the dense scaffolding tissue within pancreatic tumors, which is a major barrier to treatment and contributes to the cancer’s well-known chemotherapy resistance.