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CRISPR and Genome Editing – News and Features

Double helix structure of DNA.

Enhanced Gene Editing System Enables Therapeutic Gene-Sized Edits in Human Cells

The gene-editing approach uses prime editors and evolved enzymes called recombinases, and could pave the way to effective one-size-fits-all gene therapies for diseases such as cystic fibrosis.
A red ant.

Essential Ant Protein Enables Sense of Smell and Stops Cell Death

The protein Orco is crucial for the development of olfactory cells in ants, finds a new study that offers insights into the molecular and cellular basis of animal communication.
A close up of a rice plant.

CRISPR Technology Used To Edit Photosynthesis for the First Time

A team from the Innovative Genomics Institute at the University of California, Berkeley (UCB) has produced an increase in gene expression in a food crop by changing its upstream regulatory DNA.
A hand holding a test tube in front of a 3D structure of a DNA helix.

Bilateral Gene Therapy Restores Hearing in Children with Inherited Deafness

A new clinical trial in Shanghai, China, in partnership with Mass Eye and Ear researchers, demonstrated the restoration of hearing in both ears in five children born with autosomal deafness caused by mutations in the OTOF gene.
A strand of RNA.

Novel Method Unveils Cellular Coordination of Gene Transcription

By capturing short-lived RNA molecules, scientists can map relationships between genes and the regulatory elements that control them.
Scientist in a lab coat holding a large red and white drug capsule. Inside the drug is a molecular structure and yellow futuristic-looking dots.

Implementing AI in Drug Discovery

The four main considerations that any leader should take into account to successfully implement AI in their organization are explored here.
Female scientist tapping on a digital tablet performing pharmaceutical industry research and data analysis
Industry Insight

Collaborative AI Partnership Hopes To Shape the Future of Drug Discovery

Sanofi, Formation Bio and OpenAI are collaborating to build AI-powered software to accelerate drug development. The three teams will combine data, software and tuned models to develop custom, purpose-built solutions for drug discovery.
Vaccine vials.

CMV-Based Vaccine Shows Promise in Fighting Cancer

An Oregon Health & Science University-developed platform for cytomegalovirus-based vaccines shows promise as a “shield” against cancer. OHSU researchers used CMV to transport cancer-related antigens that would cause an immune response.
Double helix structure of DNA.

CRISPR Mapping Reveals “Switches” for Vital Immune Genes

Research reveals previously unknown regulatory workings of genes that control T cells, with findings that benefit our understanding of immune regulation and autoimmunity, and could be used in the development of cancer immunotherapies.
Cancer cells.

Cancer-Killing Therapeutics Delivered Into Cells Using “Cloaked” Proteins

An interdisciplinary collaboration has designed a way to “cloak” proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat.