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Drug Kinetics – News and Features

An elderly couple looking out to sea.

Cancer Drug Could Open Doors to New Parkinson’s Treatment

A study has shown that Rucaparib and its main metabolite M324 exhibit differential activities. The paper has analyzed Rucaparib and M324, making a computational prediction of the metabolite’s activity.
A small bandage.

Nanofiber Bandages Fight Infection, Speed Healing

An interdisciplinary team of researchers has identified an innovative way to harness the antioxidant and antibacterial properties of the botanical compound lawsone to make nanofiber-coated cotton bandages that fight infection.
Increasing the pore size of this chromium-containing MOF improved its ability to carry and deliver two common drugs: ibuprofen and 5-fluorouracil. Credit: Fateme Rezaei

Acid-Treated Polymers Are Superior Stores for Drug Delivery

After the twists and turns of discovering a drug molecule, pharma companies still face a mighty challenge: delivering their candidate drugs to the area of the body where they are needed.
A 3D model of a human brain.

Tackling Protein Aggregation in Alzheimer’s, Parkinson’s and Diabetes

Purdue researchers have created molecular compounds to inhibit protein aggregation linked with Alzheimer’s disease, Parkinson’s disease and Type 2 diabetes.
A close-up photo of a white robot hand.

This Metal Robot “Shapeshifts” Between Solid and Liquid To Escape Tight Spaces

Scientists have developed a strange new material that can quickly flip between a liquid and a solid state – all thanks to magnets.
Klebsiella pneumoniae bacteria attacking human blood cell.

Understanding Antibiotic Resistance When Treating Pneumonia

New research has been published that identifies positive steps towards a better understanding of antimicrobial resistance (AMR), specifically in hospital-acquired pneumonia (HAP).
A scientist holding up a glass vial.

Wearable Patch Shows Promise as Drug Delivery System

Research suggests that a wearable patch featuring electrically triggered microneedles for on-demand drug delivery could be the next frontier in treatment of neurodegenerative disorders and neurological injuries.
Researchers in a lab.

Squishy, Metal-Free Magnets To Power Robots and Guide Medical Implants

“Soft robots,” medical devices and implants, and next-generation drug delivery methods could soon be guided with magnetism—thanks to a metal-free magnetic gel developed by researchers.
Various oral medicines falling onto a tabletop.

Understanding Binding Kinetics To Optimize Drug Discovery

The efficacy of a drug candidate not only depends on the drug–target binding affinity, but also on the binding kinetics. This article outlines why studying drug binding kinetics is important in drug discovery, covering key approaches to measure the drug–target kinetics.
A lab worker.

Reusable and Recyclable, This New Hydrogel Slashes Its Environmental Impact

Princeton researchers have created a new type of hydrogel that is recyclable, yet still tough and stable enough for practical use (and reuse).