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Drug Kinetics – Webinars and Online Events

BrukerWebinarMarch20th2024HostedbyTechnologyNetworks
Webinar

Information-Rich Drug Discovery Enabled by Next-Generation Multiplexing SPR

On-Demand
In this webinar, you’ll discover how SPR can be multiplexed and automated to enable high-throughput, data-rich drug candidate screening against multiple target proteins.
Antibody breaking virus
Webinar

Antibody Specificity, Affinity and Kinetics in a Single Experiment

On-Demand
Watch this webinar to learn more about applications for screening and characterizing antibody and antibody fragments plus a label-free technology which uses surface plasmon resonance (a biophysical technology) for characterizing antibodies.
Enhancing AAV Purification in Gene Therapy Manufacturing
Webinar

Enhancing AAV Purification in Gene Therapy Manufacturing

On-Demand
This webinar highlights the latest affinity chromatography solutions for the quick and easy purification of multiple AAV serotypes across a variety of column setups.

drug discovery sciex
Webinar

Discover New Ways To Increase Your Throughput for Metabolic Stability Assays

On-Demand
In the webinar, we discuss a suite of metabolic stability assays developed using an AEMS system.
An Introduction to Grating-Coupled Interferometry (GCI) content piece image
Webinar

An Introduction to Grating-Coupled Interferometry (GCI)

On-Demand
With unrivaled flexibility and high sensitivity, the WAVE brings label-free quantification to a whole new world of applications, revolutionizing the study of biomolecular interactions.
Improving End-to-End Metabolite Identification by LC-MS/MS content piece image
Webinar

Improving End-to-End Metabolite Identification by LC-MS/MS

On-Demand
Studies on drug metabolism aid in evaluating the pharmacokinetics, pharmacodynamics and safety during discovery and development.
Precision qPCR and dPCR in the Discovery and Development of Cell and Gene Therapies content piece image
Webinar

Precision qPCR and dPCR in the Discovery and Development of Cell and Gene Therapies

On-Demand
As a cornerstone of genetic analysis in biological research, quantitative PCR (qPCR) and digital PCR (dPCR) are the most sensitive molecular methods to analyze nucleic acids and play a key role in the development of cell and gene therapies (CGT).

These tools are widely used during CGT development for example in biodistribution, pharmacokinetics and pharmacodynamics of the investigational lead molecule. But many samples, including tissues rich in nucleases, lipids and other inhibiting substances and target molecules that are short or contain modified bases, can be challenging to work with. For these types of samples, assay design using advanced strategies, concentration standards, spike-in controls and validated normalization is key for reliable analyses.

In this webinar, Dr. Kubista will present strategies for implementing reliable qPCR and dPCR analysis in CGT development while highlighting best practices for adhering to MIQE and dMIQE guidelines and the recently released ISO standard, ISO 20395:2019.
Every Breath You Take: Predicting Inhaled Drug ADME Using Lung-on-a-Chip content piece image
Webinar

Every Breath You Take: Predicting Inhaled Drug ADME Using Lung-on-a-Chip

On-Demand
The administration of drugs via inhalation into the lungs is superior to many other methods of delivery because our lungs provide a large surface area for absorption, access to the whole blood volume and comparatively little metabolic activity. Currently, there are limited in vitro models in which the absorption and permeability of drugs across the lung and into systemic circulation can be precisely measured.

In this webinar, Dr. Emily Richardson will describe novel lung-on-a-chip (LOAC), otherwise known as lung microphysiolological system, models of the alveoli and bronchi which can be used to accurately predict drug pharmacokinetics, allowing for more rapid, precise and cost-effective analysis of compounds.

Exploiting the timsTOF and MALDI-2 Platforms to Assess Pharmacodynamics and Pharmacokinetics in Preclinical Models content piece image
Webinar

Exploiting the timsTOF and MALDI-2 Platforms to Assess Pharmacodynamics and Pharmacokinetics in Preclinical Models

On-Demand
An integrated evaluation of the pharmacodynamic and pharmacokinetic properties of a drug is essential for successful translation to the clinic. However, cost-effective methods to measure these parameters at the systems level in pre-clinical models are lacking. Here, we introduce a timsTOF and MALDI-2 workflow to evaluate therapeutic activity. The platform combines ion mobility, mass spectrometry-based imaging, absolute drug quantitation across different biological matrices, in vivo isotope tracing, and global metabolome analysis in the adult zebrafish.
Feel the Need, the Need for Speed: Advances in RapidFire-MS Analyses for Faster, Larger Runs with Less Sample Presentation Session 2 content piece image
Webinar

Feel the Need, the Need for Speed: Advances in RapidFire-MS Analyses for Faster, Larger Runs with Less Sample Presentation Session 2

On-Demand
We will explore how these advances are being utilized, both individually and in tandem, as we discuss a variety of new applications demonstrating the benefits of this improved, fully integrated system.
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