Drug Kinetics – Webinars and Online Events

Webinar
Improving End-to-End Metabolite Identification by LC-MS/MS
On-Demand
Studies on drug metabolism aid in evaluating the pharmacokinetics, pharmacodynamics and safety during discovery and development.

Webinar
Precision qPCR and dPCR in the Discovery and Development of Cell and Gene Therapies
On-Demand
As a cornerstone of genetic analysis in biological research, quantitative PCR (qPCR) and digital PCR (dPCR) are the most sensitive molecular methods to analyze nucleic acids and play a key role in the development of cell and gene therapies (CGT).
These tools are widely used during CGT development for example in biodistribution, pharmacokinetics and pharmacodynamics of the investigational lead molecule. But many samples, including tissues rich in nucleases, lipids and other inhibiting substances and target molecules that are short or contain modified bases, can be challenging to work with. For these types of samples, assay design using advanced strategies, concentration standards, spike-in controls and validated normalization is key for reliable analyses.
In this webinar, Dr. Kubista will present strategies for implementing reliable qPCR and dPCR analysis in CGT development while highlighting best practices for adhering to MIQE and dMIQE guidelines and the recently released ISO standard, ISO 20395:2019.
These tools are widely used during CGT development for example in biodistribution, pharmacokinetics and pharmacodynamics of the investigational lead molecule. But many samples, including tissues rich in nucleases, lipids and other inhibiting substances and target molecules that are short or contain modified bases, can be challenging to work with. For these types of samples, assay design using advanced strategies, concentration standards, spike-in controls and validated normalization is key for reliable analyses.
In this webinar, Dr. Kubista will present strategies for implementing reliable qPCR and dPCR analysis in CGT development while highlighting best practices for adhering to MIQE and dMIQE guidelines and the recently released ISO standard, ISO 20395:2019.

Webinar
Every Breath You Take: Predicting Inhaled Drug ADME Using Lung-on-a-Chip
On-Demand
The administration of drugs via inhalation into the lungs is superior to many other methods of delivery because our lungs provide a large surface area for absorption, access to the whole blood volume and comparatively little metabolic activity. Currently, there are limited in vitro models in which the absorption and permeability of drugs across the lung and into systemic circulation can be precisely measured.
In this webinar, Dr. Emily Richardson will describe novel lung-on-a-chip (LOAC), otherwise known as lung microphysiolological system, models of the alveoli and bronchi which can be used to accurately predict drug pharmacokinetics, allowing for more rapid, precise and cost-effective analysis of compounds.
In this webinar, Dr. Emily Richardson will describe novel lung-on-a-chip (LOAC), otherwise known as lung microphysiolological system, models of the alveoli and bronchi which can be used to accurately predict drug pharmacokinetics, allowing for more rapid, precise and cost-effective analysis of compounds.

Webinar
Exploiting the timsTOF and MALDI-2 Platforms to Assess Pharmacodynamics and Pharmacokinetics in Preclinical Models
On-Demand
An integrated evaluation of the pharmacodynamic and pharmacokinetic properties of a drug is essential for successful translation to the clinic. However, cost-effective methods to measure these parameters at the systems level in pre-clinical models are lacking. Here, we introduce a timsTOF and MALDI-2 workflow to evaluate therapeutic activity. The platform combines ion mobility, mass spectrometry-based imaging, absolute drug quantitation across different biological matrices, in vivo isotope tracing, and global metabolome analysis in the adult zebrafish.

Webinar
Feel the Need, the Need for Speed: Advances in RapidFire-MS Analyses for Faster, Larger Runs with Less Sample Presentation Session 2
On-Demand
We will explore how these advances are being utilized, both individually and in tandem, as we discuss a variety of new applications demonstrating the benefits of this improved, fully integrated system.

Webinar
Feel the Need, the Need for Speed: Advances in RapidFire-MS Analyses for Faster, Larger Runs with Less Sample Presentation Session 1
On-Demand
We will explore how these advances are being utilized, both individually and in tandem, as we discuss a variety of new applications demonstrating the benefits of this improved, fully integrated system.

Webinar
From Dose to Circulation – Determination of Drug Oral Bioavailability Using a Gut–Liver Microphysiological System
On-Demand
In this webinar, Dr. Yassen Abbas will discuss how CN-Bio’s gut–liver MPS can be used for in vitro determination of oral bioavailability.

Online Event
Advances in Drug Discovery and Development 2021
On-Demand
Accessed via mobile, tablet or PC, this inaugural free-to-attend event will provide those working within academia and pharmaceutical development the opportunity to hear from experts within the field. Focus will be given to the latest advances in small molecule drug discovery and development, biopharma and biotechnology.

Webinar
Liver-on-Chip and In Silico Modeling for Quantitative Drug Metabolism Studies
On-Demand
This webinar will examine the benefits of combining LOAC with in silico modeling to explore clinical PK predictions of specific reference drugs, including investigations into the intrinsic clearance determinations for high metabolically stable compounds and the quantitation of fractions metabolized by specific enzymes.

Webinar
Bringing Life to PK Profiles – In Vivo-Relevance From an In Vitro Environment
On-Demand
In drug development, microphysiological systems (MPS) are utilized to develop in vitro biological models that can generate more physiologically- and human-relevant data.
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