Gene and Cell Therapy – Multimedia

Droplet Digital PCR (ddPCR) is a refined form of digital PCR that offers a scalable and practical method for the absolute quantification of nucleic acids. 2021 marks ten years since the advent of ddPCR and in that time it has revolutionized discovery, development and quality control of biopharmaceuticals such as antibody-based biologics, vaccines, and cell and gene therapies.

What if we could re-educate patient’s immune system in Type 1 Diabetes to accept pancreatic islets? That's the current focus of Dr. Leo Ferreira's research, in which he is exploring the use of regulatory T cells as living drugs to treat T1D. He explains all in this Teach Me in 10 video.

Lucy Lawrence will be speaking with Mark and hearing fascinating stories from throughout his career within the cancer immunology space, as well as asking more about targets that show particular promise and the greatest challenges in making them available.

Over the last decade, the number of clinical trials involving recombinant adeno-associated viral (AAV) vectors has dramatically increased, the diversity of serotypes has expanded and the demand for larger quantities of highly purified material manufactured to cGMP standards has rocketed.

In medicine, gene therapy is the process where nucleic acids are delivered to a patient’s cells as a therapeutic drug to treat an array of genetic diseases. All gene therapies utilize either viral or non-viral vectors to deliver the DNA or RNA into the host cell.

An AAV is a non-enveloped virus with a lack of pathogenicity, low immunogenicity, broad tropism and persistent transgene expression in both proliferating and quiescent cells. This makes AAVs an attractive choice for creating viral vectors for gene therapy for a variety of diseases.

Cell and gene therapies are continuing to gain popularity, with 15 now FDA approved and hundreds more in development. While these treatments are promising, managing safety and effectiveness in patients is complex.

One of the more promising types of cancer immunotherapy involves engineering immune cells to recognize and attack cancer.

The successful use of immunotherapies to help combat cancer has expanded rapidly in the last few years, with many therapies now approved for clinical use.

Download this compendium to discover solutions for bioanalysis of antibody drugs, peptide mapping and detection of protein aggregates.