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Mass Spectrometry – Multimedia

App Note / Case Study

Proton Transfer Reaction - Mass Spectrometry

Dioxin surrogates and VOC emissions online measurement
Novel Developments in Proton-Transfer-Reaction Mass-Spectrometry (PTR-MS): Switchable Reagent Ions (PTR+SRI-MS) and ppqv Detection Limit content piece image
Poster

Novel Developments in Proton-Transfer-Reaction Mass-Spectrometry (PTR-MS): Switchable Reagent Ions (PTR+SRI-MS) and ppqv Detection Limit

Proton Transfer Reaction - Mass Spectrometry (PTR-MS) is a well established technique for real-time trace gas analysis. This poster reports the latest developments in this field.
Proton-Transfer Reaction Time of Flight Mass-Spectrometry (PTR-TOF-MS): Comparison of Compact-Time of Flight (C TOF) and High Resolution-Time of Flight (HRS TOF) Platforms content piece image
Poster

Proton-Transfer Reaction Time of Flight Mass-Spectrometry (PTR-TOF-MS): Comparison of Compact-Time of Flight (C TOF) and High Resolution-Time of Flight (HRS TOF) Platforms

This poster outlines the latest developments in PTR-TOFMS technology which exceed previously reported TOF setups in terms of sensitivity, detection limits and fast response time.
Specificity of small molecule inhibitors for deubiquitinating enzymes in living cells assessed by activity-based proteomics content piece image
Poster

Specificity of small molecule inhibitors for deubiquitinating enzymes in living cells assessed by activity-based proteomics

Small molecular compounds (PR-619 and P22077) was assessed for their abilities to inhibit DUB function in crude extracts and in cells. Activity-based profiling combined with quantitative mass spectrometry revealed the inhibitory capacity of a broad range of DUBs by the PR-619, whereas P22077 showed specificity towards subsets of DUBs including USP7 in cells. Our results demonstrate the usefulness of activity-based quantitative proteomics to monitor inhibition of endogenous DUBs in vivo.
Impacts of climate on water-use and water-use efficiency of woodlands in the Sudanese Sahel region: a modelling study content piece image
Poster

Impacts of climate on water-use and water-use efficiency of woodlands in the Sudanese Sahel region: a modelling study

This poster dealt with the impacts of climate on water-use and water-use efficiency of woodlands in the Sudanese Sahel region. Results are based on global circulation models (GCMs).
App Note / Case Study

RADAR, a Xevo TQ-S function, combined with Low-High pH UPLC Screening for Fast, Simple Bioanalysis Methods Development

Here, we demonstrate the productivity gains possible with Xevo TQ-S for use in bioanalytical methods. Xevo TQ-S employs a unique RADAR functionality to collect data in the time scale of a narrow 1- to 2-second peak.
Capture Compounds towards a targeted reduction of proteome complexity content piece image
Poster

Capture Compounds towards a targeted reduction of proteome complexity

Capture Compound Mass Spectrometry (CCMS) enables the enrichment of proteins based on their functionality. CCMS is commercialized as kits for research applications and in collaborations with pharmaceutical companies. The focus is on investigating mechanisms of drug action and avoidance of toxic effects of small molecule drugs.
Proteomic non-small cell lung carcinoma biomarker screening in bronchoalveolar lavage fluid content piece image
Poster

Proteomic non-small cell lung carcinoma biomarker screening in bronchoalveolar lavage fluid

Using a standardized method to acquire MALDI-TOF proteome profile spectra of bronchoalveolar lavage fluid (BALF), we have shown the upregulation of histatin 3 and calgranulin C in a small pilot cohort of NSCLC patients. This pilot study serves to demonstrate that it is feasible to screen a larger NSCLC patient cohort for BALF proteome level biomarkers in a clinical setting.
A Novel Approach to Internal Standardization in LC/MS/MS Analysis; Sensitive LC/MS/MS Analysis of Gentamicin content piece image
Poster

A Novel Approach to Internal Standardization in LC/MS/MS Analysis; Sensitive LC/MS/MS Analysis of Gentamicin

A novel approach to internal standardization in LC/MS/MS is demonstrated. Gentamicin, a multi-component aminoglycoside, is derivatized with propyl-d7 chloroformate making the internal standard. Gentamicin components in the samples are derivatized with non-labeled propyl chloroformate making them analogous to the internal standard. Additional benefits of the derivatization are increased hydrophobicity and excellent MS/MS fragmentation.
Predicting hepatotoxicity: Reactive metabolite trapping using glutathione and freshly isolated hepatocytes content piece image
Poster

Predicting hepatotoxicity: Reactive metabolite trapping using glutathione and freshly isolated hepatocytes

This poster presents our results to date using clozapine (a compound known to be associated with GSH-adduct formation) as substrate and using stable isotope GSH (GSH13C2,15N) to enhance specificity. In addition, all analyses have been conducted using an Waters Acquity UPLC-MS/MS. Results we have obtained in hepatocytes are compared against findings using human liver microsomes (HLM).
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