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Multiomics – News and Features

A 3D model of a human kidney.
News

PFAS-Linked Gut Microbiome Changes May Contribute to Kidney Damage

A study by USC researchers found that PFAS exposure is associated with reduced kidney function in young adults, with disruptions in the gut microbiome and related metabolites potentially explaining up to 50% of this decline.
A human figure made up of molecules.
News

Key Metabolites Affecting Lifespan Identified

A study from the Buck Institute reveals that threonine, an essential amino acid, could extend lifespan in both fruit flies and humans. By utilizing machine learning and systems biology, researchers linked key metabolites between species.
Cell therapy.
News

Intrinsic CAR-T Cell Factors May Influence Clinical Success

A study highlights that the efficacy of varni-cel, a CAR-T therapy for B-ALL, hinges on three key markers: CD4 ratio, exhaustion signals and gamma-delta T-cell expansion. This research may enhance remission rates.
Colon cancer cells, labelled in red and green.
News

Cancer Risk Linked to “Guardian of the Genome” in Ulcerative Colitis

Researchers have shed new light on the role of p53 in the pathogenesis of ulcerative colitis, which is linked to an increased colon cancer risk.
Two side-by-side enzyme structures, one the bacterial version of the enzyme, the other the human version.
News

Beneficial Gut Microbe Linked to Growth Benefits in Malnourished Children

Researchers have discovered a gut bacterial enzyme with previously unknown metabolic capabilities linked to growth benefits in malnourished children.
Protein structure.
News

Gluing Two Proteins Together Drives Cancer Cells To Self-Destruct

Stanford Medicine researchers discovered a method to induce cancer cell death by manipulating proteins involved in apoptosis. By tethering BCL6 to CDK9, they activated apoptosis-promoting genes in lymphoma cells.
Multiplex single-cell protein profiling of human kidney. Credit: The Human Protein Atlas.
News

The Human Protein Atlas Launches Version 24

At this year’s HUPO annual meeting, the 24th version of the Human Protein Atlas has launched. We interviewed the HPA's program director, Professor Mathias Uhlén, to learn about its new features.
Protein structure.
News

Unraveling Protein Interactions in Cells

Researchers have developed an advanced technique to analyze protein interactions within cells, revealing that cellular stress significantly alters these interactions. The study demonstrates how this understanding could inform drug development.
Cancer cells.
News

Key Genetic Factors Identified for Predicting Survival for Black Patients with Leukemia

Researchers found that specific genetic mutations in Black patients with acute myeloid leukemia (AML) significantly affect survival outcomes. Their findings stress the importance of including ancestry-specific factors in AML risk stratification.
Woman applying cream to hands
News

Impact of Skin Pigmentation On Drug Bioavailability

The researchers argue that a sizable proportion of drugs and other compounds can bind to melanin pigments in the skin, leading to differences in how bioavailable and efficacious these drugs and other compounds are in people with varying skin tones.
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