Multiomics – News and Features

In this article, we highlight how target discovery has advanced and explore the growing role that computational approaches are playing in modern drug target identification.

An antimalarial drug, in combination with drugs that target resistance mechanisms, could be used to treat cancer.

A study by USC researchers found that PFAS exposure is associated with reduced kidney function in young adults, with disruptions in the gut microbiome and related metabolites potentially explaining up to 50% of this decline.

A study from the Buck Institute reveals that threonine, an essential amino acid, could extend lifespan in both fruit flies and humans. By utilizing machine learning and systems biology, researchers linked key metabolites between species.

A study highlights that the efficacy of varni-cel, a CAR-T therapy for B-ALL, hinges on three key markers: CD4 ratio, exhaustion signals and gamma-delta T-cell expansion. This research may enhance remission rates.

Researchers have shed new light on the role of p53 in the pathogenesis of ulcerative colitis, which is linked to an increased colon cancer risk.

Researchers have discovered a gut bacterial enzyme with previously unknown metabolic capabilities linked to growth benefits in malnourished children.

Stanford Medicine researchers discovered a method to induce cancer cell death by manipulating proteins involved in apoptosis. By tethering BCL6 to CDK9, they activated apoptosis-promoting genes in lymphoma cells.

At this year’s HUPO annual meeting, the 24th version of the Human Protein Atlas has launched. We interviewed the HPA's program director, Professor Mathias Uhlén, to learn about its new features.

Researchers have developed an advanced technique to analyze protein interactions within cells, revealing that cellular stress significantly alters these interactions. The study demonstrates how this understanding could inform drug development.