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Neurodegeneration – Multimedia

Lab Experimen
App Note / Case Study

A High-Throughput Platform for Fluorescence Image-Based Neurite Outgrowth Analysis

This application note introduces an automated solution for flexible and sensitive multichannel analysis of neurite outgrowth for high-throughput assays.
A headshot on top of cancer cells.

Viruses and Cancer – From Cause to Cure

Learn about viruses and cancer in our latest episode of Teach Me in 10.

How To Accelerate Research and Drug Discovery in Motor Neuron Disease: A Deep Dive Into Precision Reprogrammed Human iPSC-Derived Motor Neurons

In the Teach Me in 10 video, Dr. Marcos Herrera-Vaquero, bit.bio discusses motor neurons and their critical role in Motor Neuron Diseases (MNDs) such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA).
Neuro Program
App Note / Case Study

Precision Reprogrammed iPSC Models for High-Throughput Drug Discovery

This app note delves into the role of TDP-43 protein aggregates in the disease's progression. Charles River Laboratories and bit.bio present a breakthrough in ALS research with genetically matched ioGlutamatergic Neurons, providing a crucial in vitro model.
Technology Networks - weekly science roundup.

Weekly Science News Roundup

Your weekly science news roundup is here.
Modeling Neurodegeneration

Discover a New Approach to Modeling Neurodegeneration

This poster demonstrates how a novel, precise and highly controlled iPSC reprogramming technology overcomes these limitations and enables the generation of mature cell types and isogenic models of neurodegenerative disease.
Bit.bio Microglia Neurodegeneration

Functional, Reprogrammed Microglia To Study Neurodegeneration

Microglia play key roles in neurogenesis, synaptic remodeling, and are the first responders to infection in the brain. Hence, disease-relevant cell models are key to the success of neuroimmune and neurodegeneration research.
Four Hacks for Culturing Neurons content piece image
How To Guide

Four Hacks for Culturing Neurons

Human iPSC-derived excitatory neurons provide helpful physiologically relevant cell models to investigate neurodevelopmental and neurodegenerative disorders, although achieving healthy neuronal cultures can be challenging.
Modeling Neurodegeneration Using a Human Isogenic System content piece image

Modeling Neurodegeneration Using a Human Isogenic System

Patient-derived induced pluripotent stem cells (iPSCs) enable generation of in vitro models that can recapitulate human disease phenotypes. However, conventional human iPSC differentiation protocols are often lengthy, inconsistent and difficult to scale.
Modeling Neurodegeneration: A Next-Generation Approach To Study Huntington’s Disease content piece image

Modeling Neurodegeneration: A Next-Generation Approach To Study Huntington’s Disease

To overcome these challenges, researchers have developed a proprietary gene-expression targeting strategy that can rapidly reprogram hiPSCs into pure somatic cell types in a scalable manner. This approach was used to develop a Huntington’s disease (HD) model carrying a 50CAG expansion in the huntingtin (HTT) gene.