Neurodegeneration – News and Features

A study reveals that the APOE3-R136S mutation delays Alzheimer’s disease by inhibiting the cGAS-STING immune pathway. This mutation suppresses inflammation in brain-resident immune cells, offering protection against tau accumulation.

New research identified a protein called protein disulfide isomerase that helps repair serious DNA damage, providing a target to prevent and treat aging.

Researchers at the University of Illinois Urbana-Champaign have developed a fast, noninvasive MRI method to map whole-brain metabolism. The technique identifies early biochemical changes in the brain.

Single-cell analysis of brain tissue has revealed genome alterations linked to PTSD, offering insights into targeted treatments.

A new approach induces the patient’s body to produce its own CAR-T cells, relying on the same messenger RNA (mRNA) technology that was instrumental for some COVID-19 vaccines.

The study reveals a significant relationship between elevated iron levels in the brain and greater cellular damage in individuals with both Down syndrome and Alzheimer’s disease.

3D printers can be used to make organoids from a patient's cells that resemble human nerve tissue to test new amyotrophic lateral sclerosis treatments.

A new lipid-based pathway essential for memory formation has been discovered by University of Queensland researchers – a breakthrough that could lead to treatments for post-traumatic stress disorder (PTSD).

A recent study has shown that common financial behaviors, captured through routine banking data, can serve as early indicators of cognitive decline in older adults, up to a decade before formal diagnosis.

Researchers report the initial development of a system that inexpensively screens for PD from the odors in a person’s earwax.