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Neurodegeneration – News and Features

A sand timer with sand in the top and bottom of the hourglass sits on some rocks.

“Time Cells” in the Mouse Brain Are Essential for Complex Learning

A population of "time cells" in the brain is essential for learning complex behaviors where timing is critical.
A 3D model of a human brain.

New Wearable Device Modulates Brain Neurons in Mice

McKelvey School of Engineering researchers have developed a noninvasive technology combining a holographic acoustic device with genetic engineering that allows them to precisely target affected neurons in the brain.
Neurotransmitters in a synapse.

Changing People’s Brain Dopamine Levels Impacts Their Mentalizing Abilities

Changing the levels of dopamine in a person's brain affects their ability to understand mental states in themselves and in other people.
AN old woman and a young woman in a garden.

Could a Protein Aggregation Clock Accurately Measure Aging?

Could measuring protein clumps in our cells be a new way to find out our risk of getting age-related diseases?
Neurons degenerating.

Maternal Alzheimer's Gene Linked to Higher Brain Amyloid Risk

Mass General Brigham researchers analyzed 4,400 cognitively unimpaired adults with amyloid imaging, finding increased amyloid in those who reported that their mothers had symptoms of Alzheimer’s disease (AD).
An old person holds their hands in their lap.

Multiomics Approach Identifies Four Distinct Molecular Profiles of Alzheimer’s

A multiomics approach has identified four distinct molecular profiles of Alzheimer's, one of which was associated with worse cognitive function.
Drugs of different colors, shapes and sizes in half-filled blister packs.

Blood Clot-Targeting Drug Candidates Developed Through Computer-Aided Design

A team of researchers has created a new series of drug candidates against a hard-to-target receptor involved in the formation of blood clots.
Bacteria in the gut.

Transplanting Gut Microbes From Aged Mice Induces Age-Related Inflammation

When the gut microbes of aged mice were transplanted into young, germ-free mice, the recipients experienced an increase in inflammation, suggesting that the gut microbiome plays a role in the inflammation that occurs with aging.
Neural networks of the human brain; a 3D illustration.

Huntington’s Disease Impacts Brain Blood Vessels Even Before Symptoms Appear

The genetic disease Huntington’s not only affects nerve cells in the brain but also has widespread effects on microscopic blood vessels according to research.
Neural connections.

Chilled Brain Molecules Unravel Epilepsy Drug’s Mechanism

Scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.