Neurodegeneration – News and Features

Researchers propose that increasing potassium intake, rather than solely reducing sodium, could be a more effective strategy for managing hypertension. The study highlights sex differences in the potassium-to-sodium ratio’s effect on blood pressure.

Researchers have uncovered the critical role of the "fuzzy coat" of α-synuclein in forming Lewy bodies associated with Parkinson's disease and Lewy body dementia.

Researchers at the University of Gothenburg have identified a small molecule, PZL-A, that restores function in the defective POLG enzyme, critical for mitochondrial DNA replication. The compound has shown promise in enhancing mitochondrial function.

A study led by Northwestern Medicine used CRISPR interference to identify Commander proteins involved in Parkinson’s disease risk. These proteins play a key role in lysosomal function, and targeting them could offer new therapeutic options.

The detection of peripheral neural stem cells could transform the treatment of Parkinson's disease and spinal cord injuries.

Researchers have dosed the first participant in a clinical trial of an investigational medicine designed to lower the amount of amyloid precursor protein for the potential treatment of Alzheimer’s disease.

A study suggests new avenues for drug development to reduce the risk of developing both Parkinson’s and skin cancer by targeting the function of the alpha-synuclein protein, which appears to have a critical role in regulating cellular functions.

Researchers examined brain tissue to look for signs of brain injury including tau tangles and hyaline arteriolosclerosis.

A recent study at Tufts University showed that vitamin K deficiency in mice led to impaired memory, reduced neurogenesis, and increased brain inflammation. These findings suggest that vitamin K plays a crucial role in supporting brain health.

People with low levels of low-density lipoprotein cholesterol (LDL-C) in their blood have a lower risk of dementia, a new study reports.