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Neurodegeneration – News and Features

A neuron.

Targeting Abnormally Active B-Cell Metabolism Reduces Multiple Sclerosis Symptoms

Abnormally active metabolism in B cells drives pro-inflammatory responses that lead to myelin being attacked by T cells. By targeting B cell metabolism, multiple sclerosis flare-ups are reduced.
A purple human brain.

Gene Delivery Vehicle Shows Promise for Human Gene Therapy

Scientists have engineered an adeno-associated virus (AAV) that efficiently crosses the blood-brain barrier in human cell models and delivers genes throughout the brain in humanized mice.
A fork wrapped in a tape measure.

Weight Loss Drug Tested in Mice May Be More Effective Than Existing Medicines

A recent paper in Nature describes a promising new therapy for obesity that leads to greater weight loss in mice than existing medications. The approach smuggles molecules into the brain's appetite centre and affects the brain's neuroplasticity.

Researchers Identify Symptom-Free Alzheimer’s Patients

Researchers looked at brains from the Netherlands Brain Bank. The team found a subgroup of people who had Alzheimer’s disease processes in their brains, but did not show any clinical symptoms while alive.
Neurons that are degenerating.

Rapid Cell Aging Discovered in Certain Brain Cells Linked to Alzheimer’s

Engineers at the University of California San Diego have discovered that some brain cells age more rapidly than others, and they are disproportionately abundant in individuals afflicted with Alzheimer’s disease.
Shelves of alcohol bottles.

New Gel Breaks Down Alcohol in the Body

Researchers at ETH Zurich have developed a protein-​based gel that breaks down alcohol in the gastrointestinal tract without harming the body. In the future, people who take the gel could reduce the harmful and intoxicating effects of alcohol.
A scanning electron microscope image of virion.

Gene Therapy Eliminates 90% of Herpes Infection in Mouse Models

Preclinical studies of a new gene therapy show it can eliminate 90% or more of herpes infection and suppress how much virus can be released by an individual.
A woman in bed sleeping.

Sleep’s Role in Clearing Brain Toxins Questioned by Scientists

Over the past decade, the leading explanation for why we sleep has been that it provides the brain with an opportunity to flush out toxins. However, a new study indicates that this may not be true.
Double helix structure of DNA.

Designing Peptoids That Mimic Nature’s Helices

Nature is filled with extraordinarily precise molecular shapes that fit together like a hand in glove. Proteins, for example, can assemble into a wide variety of well-defined shapes that grant them their function.
A generated image of a human brain on top of a computer chip.

Alzheimer’s Disease Types Linked to Rate of Cognitive Decline by New Tool

Mayo Clinic researchers have discovered a series of brain changes characterized by unique clinical features and immune cell behaviors using a new corticolimbic index tool for Alzheimer's disease, a leading cause of dementia.