Neurodegeneration – News and Features

Analyzing donated brains from deceased people with Alzheimer’s disease who received amyloid-beta immunization, researchers found that when these treatments work, the brain’s immune cells help to restore a healthier brain environment.

Johns Hopkins scientists have developed an mRNA “booster” as a potential new way to treat rare genetic diseases marked by too low levels of specific cellular proteins.

Reprogrammed stem cells to replace dopamine cells in the brain may offer hope for Parkinson's treatment as a phase 1 trial to test the approach launches.

For the early detection of Alzheimer's disease, so-called p-tau proteins in the blood are not as disease-specific as previously assumed: the biomarkers in the blood are also elevated in people with amyotrophic lateral sclerosis.

A study finds that a high-fat diet causes memory impairment and brain inflammation in older rats within three days. Unlike young rats, aged rats showed cognitive decline before obesity developed.

Researchers may have discovered how the female brain remains resilient in aging, answering the age-old question of how most women outlive men and retain their cognitive abilities longer.

A study from Mass General Brigham found that women over 70 who used menopausal hormone therapy (HT) more than a decade earlier accumulated tau, a key Alzheimer’s marker, at a faster rate. The findings highlight the importance of timing in HT use.

Researchers have uncovered new insights into how metabolic dysfunction contributes to Parkinson’s disease.

A study reveals how glutamate drives tau accumulation in Alzheimer’s and related disorders. Researchers found that blocking the gene KCTD20 activates lysosomes, helping clear toxic tau proteins in lab models.

The quantum properties of ultra-thin semiconductors, which trap electrons in two dimensions, can be used to sense the biological electrical activity of living cells with high speed and resolution.