Neurodegeneration – News and Features

Researchers have developed a blood test that detects Alzheimer’s disease and stages its progression, offering an alternative to costly and less accessible brain imaging techniques like PET scans. The test measures levels of MTBR-tau243.

Recent findings suggest that mitochondrial-targeted therapy, either by reducing reactive oxygen species production or inhibiting gasdermin D, may prevent triggering atrial fibrillation.

Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells. The study found that mutations to VPS35, a key player in this pathway, can prevent chemotherapy-induced cell death.

A novel PET imaging method successfully quantifies COX-2 enzyme levels in the human brain. This technique opens the door for earlier detection, monitoring of disease progression, and evaluating anti-inflammatory treatments for brain disorders.

A new study reveals that intermittent fasting increases sexual activity in male mice by reducing serotonin levels, potentially linked to a decrease in tryptophan availability.

New research has shed light on the cellular quality controllers that prevent defective protein blueprints.

Researchers have developed a laboratory model that mimics the pathological aggregation of TDP-43, a key protein in ALS and frontotemporal dementia. The model, based on human cells, recapitulates TDP-43’s mislocalisation and aggregation.

Eukaryotic cells form the foundation of complex life, their defining feature being the presence of membrane-bound organelles. This article details the structure of eukaryotic cells and provides examples of eukaryotes.

The brain's cholesterol regulation and metabolism mechanisms may make some neurons more vulnerable to damage in the early stages of Alzheimer's disease.

Researchers discovered that ATP-sensitive potassium (KATP) channels in the brain play a pivotal role in sleep regulation. These energy sensors help maintain sleep-wake cycles and smooth transitions between them.