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Neurodegeneration – News and Features

A 3D model of a human brain.
News

Study Reveals Expanding and Contracting Blood Vessels in Awake Mouse Brain

Researchers have, for the first time, visualized the full network of blood vessels across the cortex of awake mice, finding that blood vessels rhythmically expand and contract leading to “waves” washing across the surface of the brain.
Floating cells on an orange background.
Article

Challenges and Solutions in Cell Therapy Development

In this article, we explore how researchers are tackling some of the challenges preventing cell therapies from being more widely used. We also outline advances in manufacturing and regulatory approval processes that will help expand patient access to life-changing treatments.
B cells segregating specific antibodies to mark and subsequently destroy a virus
News

Metabolic Inhibition Offers a New Approach To Combat Epstein-Barr Virus

Inhibiting a specific metabolic pathway in EBV-infected B cells can diminish infection and reduce the risk of downstream disease. A class of “failed” inhibitor drugs may now receive a second chance in applications aimed at dampening EBV infection.
Neurons.
News

Researchers Discover “Off Switch” for Brain Cells Using Light

Researchers from Duke-NUS Medical School have found that a new class of light-sensitive proteins are capable of turning off brain cells with light, offering scientists an unprecedentedly effective tool to investigate brain function.
Protein structure.
News

Novel Method Reveals Tissue-Specific Protein Interactions

Researchers developed a novel chemical biology approach to label proteins from specific cells with a bifunctional amino acid probe that allows labelled proteins to be isolated and captures protein-protein interaction through photo-crosslinking.
Neurodegeneration.
News

Clinical Trial Offers Promising Results for Alzheimer’s

A team evaluated a new drug for enhancing the brain’s resilience to changes driven by Alzheimer’s, showing promising results for patients with mild to moderate forms of the disease in its first human trial.
Two pomegranates on a plate.
News

Pomegranate Substance Improves Alzheimer’s Symptoms in Mice

A substance naturally occurring in i.a. pomegranates, strawberries and walnuts can improve memory and treatment of Alzheimer’s disease, a new study conducted at the University of Copenhagen concludes.
Cancer cells.
News

First-of-its-Kind Cancer Drug Shows Anti-Tumor Activity in Animal Models

Behind the scenes, as tumors progress and gain resistance to treatment, a protein called YB-1 quietly gives directions. Now, researchers have developed a first-of-its-kind drug that inhibits YB-1, effectively silencing those orders.
The newly developed multiplexed orthogonal base editors (MOBEs) minimize unwanted edits while still achieving high levels of efficiency.
News

Multiplexed Orthogonal Base Editors Install Multiple Point Mutations at Once

Researchers from the University of California San Diego have developed new, efficient genome editing tools called multiplexed orthogonal base editors (MOBEs) to install multiple point mutations at once
An image of a brain.
News

Protein Linked to Alzheimer’s May Shape Neuron Growth

A new study has described how a protein that helps to shape the growth of neurons – contactin-4 – also interacts with a protein involved in neurodevelopmental diseases and Alzheimer’s.
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