Screening Strategies in Drug Discovery – Multimedia

Download this listicle to learn more about high-throughput screening, mass spectrometry-based technologies, multiomics research and high-throughput drug screening.

In drug screening, conventional high-throughput applications evaluate only a few measurements and have limited breadth to detect diverse phenotypic changes caused by compound exposure.

Living Biologics - Biologics Workflow Solutions

The powerful role of precision biologics as part of therapeutic strategies becomes increasingly apparent every day. However, harnessing large molecules to create safe and effective therapies is a complex and expensive undertaking.

Speaking at the Advances in Drug Discovery & Development 2021, NanoTemper Technologies' Amit Gupta delivered his talk on the optimization of identifying challenging targets and ligands.

A Customized XF Workflow for Detection and Characterization of Mitochondrial Toxicity

Many different classes of drugs can cause drug-induced mitochondrial toxicity, which may result in brain, cardiac, liver, muscle and/or kidney injury.

Mitochondrial toxicity assessments are crucial to ensuring the safety and efficacy of candidate compounds during drug development.

Flow cytometry allows for unparalleled multiplexing, while providing the flexibility, speed and reproducibility to analyze a high number of individual events and determine their distributions.

In this episode, Lucy Lawrence and Michiel Fokkelman will discuss the concept of high content imaging of 3D-cultured organoids in combination with high throughput screening as a service for drug discovery and pre-clinical drug development.

Download this infographic to explore key milestones and assay types, innovations driving high-throughput screening (HTS) and a typical HTS workflow.

Cell painting is a powerful phenotypic screening method used to gain a deeper understanding of the effects of chemical and genetic perturbagens on cells.