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Screening Strategies in Drug Discovery – News and Features

Computer-generated image of nerve cells.

Mouse Study Raises Possibility of ALS Immunotherapy Treatment

Researchers have modulated a protein related to the immune system to slow the progress of amyotrophic lateral sclerosis (ALS) in mice.
Cancer cells.

Promising Early Trial Results for Second-Generation Cancer Therapy

Preliminary results of a study show that a novel, selective inhibitor of protein arginine methyltransferase 5 demonstrated antitumor activity in patients with advanced malignant solid tumors or B cell non-Hodgkin lymphomas.
An orange pill bottle spilling pills in a variety of sizes, shapes and colors.

Potential New Therapies To Lower “Bad” Cholesterol Discovered

A group of molecules with the potential to treat familial hypercholesterolemia, a genetic disease that causes high cholesterol levels, has been identified in a new study.
A picture of medicines.
Industry Insight

Failing Faster To Succeed Sooner in Drug Discovery

Revvity announced its newly established Scientific Centre of Excellence in Cambridge, where scientists can outsource their research needs to Revvity experts. Technology Networks visited the site to learn more about how Revvity is supporting its customers in their drug discovery efforts.
Pink tablets in a blister pack.

Existing Cancer Drug May Be Repurposed for Other Aggressive Cancers

A team of researchers has identified an existing cancer drug that could also be used to treat an aggressive subset of cancers.
Lipid nanoparticle mRNA vaccine.

High-Throughput Formulation Screening To Fine-Tune Performance Characteristics of Nanomedicines

This article discusses how marrying microfluidics with automation can provide the necessary level of control to perform high‑throughput LNP formulation screening in a cost-effective and timely manner, and how this approach can accelerate the development of new nanomedicines.
A human hand and robotic hand touch a strand of DNA.

AI Can Predict Activity of RNA-Targeting CRISPR Tools

A new study combines a deep learning model with CRISPR screens to control the expression of human genes in different ways.
Contact lens balanced on the end of a person's outstretched finger.

Microplastics Shed by Contact Lenses

Scientists have developed a method to analyze minute debris in small samples and found that contact lenses exposed to sunlight over time can shed tiny fragments of plastic, though the health impact is unclear.
An assortment of pills.

Computational Model Offers a Way To Speed Up Drug Discovery

By applying a language model to protein-drug interactions, researchers can quickly screen large libraries of potential drug compounds.
A person putting sweetener in their drink.

Artificial Sweetener Metabolite Breaks DNA

Scientists at the North Carolina State University found that a chemical compound produced through the digestion of a common artificial sweetener causes damage to DNA.