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Screening Strategies in Drug Discovery – News and Features

A human hand and robotic hand touch a strand of DNA.

AI Can Predict Activity of RNA-Targeting CRISPR Tools

A new study combines a deep learning model with CRISPR screens to control the expression of human genes in different ways.
Contact lens balanced on the end of a person's outstretched finger.

Microplastics Shed by Contact Lenses

Scientists have developed a method to analyze minute debris in small samples and found that contact lenses exposed to sunlight over time can shed tiny fragments of plastic, though the health impact is unclear.
An assortment of pills.

Computational Model Offers a Way To Speed Up Drug Discovery

By applying a language model to protein-drug interactions, researchers can quickly screen large libraries of potential drug compounds.
A person putting sweetener in their drink.

Artificial Sweetener Metabolite Breaks DNA

Scientists at the North Carolina State University found that a chemical compound produced through the digestion of a common artificial sweetener causes damage to DNA.
A person pipetting in a laboratory, with chemical structures superimposed next to them.

"Molecular Editing" Technique Aids Crafting of Pharmaceuticals and Other Compounds

Researchers add another powerful tool to their “molecular editing” kit for crafting pharmaceuticals and other valuable compounds, enabling chemists to add new elements to organic molecules at locations that were previously out of reach.
A computer-generated image of a cell.

Probe Developed That Could Reveal Insights Into Key Cellular Messenger

A ground-breaking study has led to the development of a small molecule probe that could improve our understanding of an important cellular messenger.
Floating antibodies

Recent Advances in Therapeutic Antibody Screening

This article explores the various screening technologies used in the development of therapeutic antibodies and outlines the recent advances in this area.
A schematic showing how cancer gene's RNA can be targeted.

New RNA Degrader Approach Tackles the “Mount Everest” of Cancer Targets

The "Mount Everest" of cancer genes, MYC, has been targeted by a new RNA degrader approach, where cellular recycling enzymes are directed to cancer gene RNA to remove key segments.
Cisplatin pills.

Compound Prevents Kidney Toxicity Caused by Chemotherapy Drug

Researchers in Japan identify a compound that can prevent cisplatin-induced renal toxicity and improve the outcomes of cancer treatment.
Floating cancer cells.

Protein Hyperactivation Could Kill Cancer Cells and Bacteria

Technology Networks had the pleasure of speaking with Walid A. Houry, professor of biochemistry at the University of Toronto, to find out about the discovery of compounds that can induce protease hyperactivation to kill cancer cells.