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Screening Strategies in Drug Discovery – News and Features

Bone-marrow cells of a multiple myeloma patient under the microscope.

Screening Platform Helps Search for More Effective Blood Cancer Therapies

Despite approved treatments being available, multiple myeloma remains incurable, but researchers aimed to improve treatment outcomes by testing hundreds of existing therapeutics to predict their effectiveness.
An image of a robot meeting a human hand.
Industry Insight

Supporting Reproducibility and Accelerating Workflows With Automated Systems

At SLAS 2023, Technology Networks spoke with the PerkinElmer Life Sciences and Diagnostics organization to discuss the launch of two new automated platforms. These innovative systems are designed to improve workflows such as high-throughput drug discovery screening and next-generation sequencing library prep through advances in automation technologies.
Two scientists in lab coats stand by a high-throughput screening machine.

Candidate Cervical Cancer Drugs Quickly Evaluated Using New Model

A new high-throughput screening model has been developed to assess potential drug compounds to treat cervical cancer.
A diagram showing LCA10 untreated and treated with Reserpine.

Blood Pressure Drug Shows Promise as Treatment for Blinding Childhood Disease

Researchers have identified a compound already approved by the U.S. Food and Drug Administration that keeps light-sensitive photoreceptors alive in three models of an inherited disease that often results in severe visual impairment or blindness in early childhood.
Four different tablet types sit on or around a white puzzle piece.

Fragment-Based Drug Discovery Enters the Mainstream

This article will discuss the principles of fragment-based drug discovery and will highlight some examples of recent successes in this area.
Different medications on a red background.

Could Existing Drugs Treat "Lincoln's Ataxia"?

Researchers have developed a new method to determine if FDA-approved drugs could be repurposed or improved to help patients with a rare disease of the nervous system, Spinocerebellar ataxia type 5.
Gloved hand holding a slightly open blood agar Petri dish of bacteria up to a computer screen displaying a protein structure.

Understanding Structural Biology, Its Applications and Creating a Molecular Model

In this article, we consider what structural biology tells us and the techniques used to investigate it, the role of computation and how techniques can be used together to answer questions in a range of application areas.
Three boxes with chemical structures coming from them.

New Method for Targeted Design of Molecules With AI

Researchers have combined various artificial intelligence methods to enable the targeted design of molecules with specific properties,
Gloved hands hold an agar dish and a cotton swab. In the background other agar dishes and a test tube rack can be seen.

Cell Culture – Good Practice and Advanced Methods

This article will explore the importance of cell culture quality control and highlight recent developments in this area.
Illustration of a cell culture plate with various organoids linking to the area of the human body they are from.

An Introduction to Organoids, Organoid Creation, Culture and Applications

Organoids have revolutionized biological and medical research and proven to be excellent substitutes for animal models in preclinical studies. Here, we discuss what organoids are and how they have been developed over the years to become popular research tools.