Single-Cell Analysis – News and Features

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Spatial Transcriptomics Is in a Phase of Rapid Growth
Technology Networks spoke to the most productive researcher in spatial transcriptomics, Professor Joakim Lundeberg, about the field’s rapid growth.

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Metformin Restores Endometrial Health in PCOS
A new study reveals that metformin, beyond managing blood sugar, restores endometrial health in women with PCOS. The drug improves cell adhesion and gene expression in the uterine lining, potentially reducing miscarriage risk and improving fertility.

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New Insights Into B Cell Mutations Could Improve Vaccine Strategies
Successful high-affinity B cells can proliferate under special conditions that reduce the risk of mutation. Capturing this mechanism in the lab may lead to more efficient vaccine strategies in the clinic.

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Inflammation, Not Just Plaques, May Drive Alzheimer's Progression
A new study reveals that IL-12, an inflammatory molecule, accelerates Alzheimer’s disease by damaging brain cells and preventing plaque clearance. Blocking IL-12 in mice halted disease-related changes, suggesting a potential new therapy.

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Pig Retinal Organoids Could Advance Cell Therapy for Eye Disease
Researchers have developed pig retinal organoids to understand how stem cell-derived photoreceptor cells work as a therapeutic.

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Cancer Immunotherapy Enhanced by Rewiring T-Cell Metabolism
Researchers from the VIB-KU Leuven Center for Cancer Biology, in collaboration with other scientists, have discovered a way to enhance the immune system's ability to fight cancer by reprogramming T-cell metabolism.

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How Trypanosomes Alter Their Antigen Expression To Evade the Immune System
Antigenic variation is a key mechanism by which pathogens evade the immune system. New research has shown how trypanosomes change their antigen expression.

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How Circadian Rhythms Affect Muscle Repair
Our circadian clock doesn't just dictate when we sleep – it also determines how quickly our muscles heal, with muscle injuries healing faster when they occur during natural waking hours.

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Researchers Uncover Cause of Leptin Resistance – And How To Reverse It
90% of people with obesity have leptin resistance – new research has found a mechanism involved and a way to reverse it using a well-known drug.

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Reprogramming Aggressive Cancer Cells Into Harmless Ones
UCLA scientists have identified a potential new strategy for treating glioblastoma, the deadliest form of brain cancer, by reprogramming aggressive cancer cells into harmless ones.
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