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Single-Cell Analysis – News and Features

A doctor sitting next to a model of a brain next to two pill bottles.

Researchers Identify Brain Circuit Behind Placebo-Induced Pain Relief

Research published in Nature reveals a new pain control pathway from the cortex to the cerebellum crucial to placebo analgesia – when the expectation of pain relief leads to pain alleviation without a therapeutic intervention, such as with a drug.
3D rendered enhanced scanning electron micrograph (SEM) of cancer cells at a very high magnification.

Ancient Viruses Reawaken To Fuel Modern-Day Cancer Spread

Researchers have found that DNA sequences originating from ancient viral infections can play a critical role in helping cancer to survive and thrive. The researchers suggest that silencing these sequences could help to improve cancer treatments.
Cancer cells.

Antiviral Protein Acts Both as an Ally and an Enemy in Cancer Treatment

Investigators have uncovered new details about the role of a protein called interferon regulatory factor (IRF1) in cancer progression and treatment response, offering new insight that can potentially help improve the effectiveness of cancer immunotherapy.
Pancreatic cancer cells (nuclei in blue) growing as a sphere encased in membranes (red).

Could We Make KRAS Inhibitors More Effective Against Pancreatic Cancer?

KRAS inhibitors are showing initial promise in clinical trials, but many tumors quickly develop resistance to the treatment. Now, researchers have discovered a new mechanism of resistance that suggests an opportunity to make the treatment more effective.
A stem cell dividing in two with other cells and DNA helices in the background

Unmasking the True Identity of Gut Stem Cells

Columbia researchers have found that Lgr5+ cells descend from the gut’s true stem cells. This case of mistaken identity may explain why regenerative medicine has not lived up to its promise.
A COVID-19 protein.

Why Don’t Some People Get COVID-19?

Using single-cell sequencing technology, researchers provide the most comprehensive timeline to date of how the body responds to SARS-CoV-2 exposure.
Astronaut Buzz Aldrin, lunar module pilot of the first lunar landing mission, poses for a photograph beside the deployed United States flag during an Apollo 11.

How Is the Immune System Affected by Space Travel?

Two Buck scientists led a team that has revealed for the first time how the lack of gravity affects the cells of the immune system at single cell resolution.
A pregnant person in a yellow dress holds their bump.

Placental Immune Cells Reveal the Health of Fetal Brain Cells

The health of fetal macrophages in the placenta can act as an indicator of the health of fetal brain cells, reveals a new study.
A macrophage cell.

Macrophages Promote Muscle Healing By Behaving Like Mural Cells

A new study from researchers at Uppsala University establishes that macrophage in the adult ischemic muscle induce a phenotype switch into mural cells to support restoration of functional blood flow and thereby promote healing.
Stem cells.

Gut Stem Cell Research Reveals Mistaken Cellular Identity

Two independent studies by Columbia scientists suggest that research into the gut’s stem cells over the past 15 years has been marred by a case of mistaken identity: Scientists have been studying the wrong cell.