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Therapeutic Antibodies – Multimedia

Accelerate Drug Discovery With Chromatography
Poster

Accelerating Antibody Drug Development With Subdomain-Specific Affinity Chromatography

Affinity purification platforms such as Protein A or L are well-established in the manufacturing process of therapeutic monoclonal antibodies. However, with the development of engineered modalities such as bi-specific antibodies, fragments and Fc-fusion proteins, challenges in the downstream process of these molecules arise.
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eBook

Purification Solutions for Therapeutic Antibodies

In recent years, different therapeutic antibody modalities have been developed to address different therapeutic needs.
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Podcast

Unlocking the Power of Therapeutic Antibodies

In this episode of Opinionated Science we dive into the world of therapeutic antibodies with Bio-Rad.
Simple and Fast Tracking of Drug–Antibody Ratio Distribution content piece image
App Note / Case Study

Simple and Fast Tracking of Drug–Antibody Ratio Distribution

Antibody drug conjugates (ADCs) are biotherapeutics, composed of small molecule drugs conjugated to an antibody scaffold, that have very complex molecular structures.
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Infographic

Facilitating Bispecific Antibody Drug Development Through Quality Control

This is especially critical for bispecific antibodies, which are regarded as the second generation of antibody cancer therapies.
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Video

Single-Cell Isolation: When Art Is Not Enough With Andris Abramenkovs

In this episode, we speak with Andris Abramenkovs, product manager of CellCelector technology at Sartorius.
Monitoring Intact Light Chain of Therapeutic mAbs in Human Serum Using HRAM LC-MS content piece image
App Note / Case Study

Monitoring Intact Light Chain of Therapeutic mAbs in Human Serum Using HRAM LC-MS

Download this tech note to learn how mass spectrometry has gained substantial popularity for therapeutic mAb monitoring in clinical laboratories due to its great versatility to detect both tryptic peptides and intact light and heavy chains quantitatively.
Your Guide To Efficiently Develop Antibody-Based Therapeutics content piece image
eBook

Your Guide To Efficiently Develop Antibody-Based Therapeutics

In the “Quality by Design” approach for monoclonal antibody (mAb)-based therapeutics development, stability characterization—the probability of a protein unfolding—is performed to ensure that structure and function are preserved throughout development and manufacturing.
Automated Switching Between Peptide and Glycan Mapping content piece image
App Note / Case Study

Automated Switching Between Peptide and Glycan Mapping

Glycan and peptide mapping are key analytical methodologies for the structural characterization of therapeutic proteins such as monoclonal antibodies (mAbs).
Preclinical Quantification of Trastuzumab in Rat Plasma content piece image
App Note / Case Study

Preclinical Quantification of Trastuzumab in Rat Plasma

In quantifying therapeutic peptides and proteins in biological matrices, traditional ELISA-only based techniques can suffer from high variability, narrow dynamic range, problems with selectivity and typically cannot use internal standards.
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