Vaccine Design and Testing – News and Features

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The Future of RNA Therapeutics, From Design to Delivery
Discover how RNA therapeutics are reshaping medicine, offering new treatments for previously undruggable targets.

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Novel Phospholipids Enhance mRNA Drug Delivery
A study conducted by researchers at Hokkaido University has unveiled a novel class of zwitterionic phospholipids capable of significantly enhancing the functional delivery of mRNA.

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mRNA-Based COVID-19 Vaccines Alter the Immune Systems “Long-Term Memory”
Researchers at the University of Cologne have discovered that mRNA-based COVID-19 vaccines have a persistent effect on the innate immune system. These mechanisms may help the human body to better protect itself against potential future infections.

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New Insights Into B Cell Mutations Could Improve Vaccine Strategies
Successful high-affinity B cells can proliferate under special conditions that reduce the risk of mutation. Capturing this mechanism in the lab may lead to more efficient vaccine strategies in the clinic.

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Lassa Vaccine Trial Opens
A National Institutes of Health (NIH)-sponsored clinical trial of a candidate vaccine to prevent Lassa fever has begun enrolling participants at the University of Maryland School of Medicine, Baltimore.

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Antibody Discovery Paves the Way for a Potential Strep A Vaccine
Researchers have discovered how antibodies help to protect against contagious bacterial infections caused by Strep A, including strep throat. The findings are contributing to efforts to accelerate the development of a Strep A vaccine.

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Reprogramming the Liver’s Immune Defense To Attack Pancreatic Cancer
A new technology from researchers at the California NanoSystems Institute at UCLA is aiming to turn the tables on tumors that migrate from the pancreas to the liver.

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COVID-Flu Vaccine Provides Broad and Lasting Protection in Mice
Cornell researchers have developed a new vaccine platform that could provide more robust, longer-lasting protection from COVID-19 and influenza and broader immunity to different flu strains.

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Controlled Kill Switches Improve TB Vaccine Safety
Researchers have engineered two mycobacterial strains with built-in kill switches that trigger self-destruction after immune activation. These strains enhance the safety of high-dose intravenous BCG vaccines.

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Cancer Vaccine Improves Antigen Visibility in Tumors
Researchers developed a cancer vaccine that uses tumor lysate to enhance immune recognition of solid tumors. The vaccine successfully targets melanoma, breast, lung and ovarian cancers in animal models.
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