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Vaccine Design and Testing – News and Features

Vaccine vials.

Single Typhoid Vaccine Dose Has Lasting Efficacy in Children

A single dose of the typhoid conjugate vaccine, Typbar TCV®, provides lasting efficacy in preventing typhoid fever in children ages 9 months to 12 years old, according to a new study.
Cancer cells.

mRNA Therapeutic Effective Against Ovarian Cancer in Mice

Ovarian cancer is often very aggressive and responds poorly to the therapies currently available. A recent study offers hope that this could change in the medium term.
A person receiving a vaccine shot in their arm.

No Cervical Cancer Cases Following HPV Vaccination in Scotland

No cervical cancer cases have been observed in women who received the human papillomavirus (HPV) vaccine at age 12 or 13 in Scotland since the program began in 2008, according to a new study.
Vaccine vials.

Cameroon Launches Historic Malaria Vaccine Rollout

Cameroon today launched the RTS,S malaria vaccine into its routine national immunization services, becoming the first country to do so outside the malaria vaccine pilot programme that was carried out in Ghana, Kenya and Malawi.

HIV Antibodies Protect Animals in Proof-of-Concept Study

Three different HIV antibodies each independently protected monkeys from acquiring simian-HIV (SHIV) in a placebo-controlled proof-of-concept study intended to inform development of a preventive HIV vaccine for people.
Breast cancer cells imaged by a microscope.

RNA Molecule Suppresses Breast Cancer Cell Formation

Researchers have taken a closer look at how breast cancer develops and have identified an RNA molecule that can suppress cancer formation.
COVID-19 Virus.

Novel Compound Protects Against COVID Virus in Preclinical Studies

Stapled lipopeptides successfully deter infection by the SARS-CoV-2 virus and reduce the severity of COVID-19 in tests with hamsters. Clinical trial now under way of compound's effectiveness as a nasal spray in humans.
Vaccine vials in production.

Why Do Vaccines Not Work Well in Some Older Adults?

Researchers at The Jackson Laboratory and UConn Health are rigorously investigating why vaccines don’t work as well in some older adults.
Illustration of gloved hands using scissors and tweezers to alter a DNA double helix.

Genetic Modification Techniques and Applications

Manipulating genetics has helped mankind in numerous ways. In this article, we consider genetic modification strategies, including genome editing and genetic engineering, the techniques used to achieve them and purposes to which they are applied.
A cell under fluorescent microscopy.

Unveiling Cellular Secrets, Researchers Show Location Is Everything

Messenger RNA (mRNA) is translated into proteins in the cytoplasm of cells. But rather than being a uniform “soup,” the cytoplasm is divided into multiple distinct compartments or regions.