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Western Blot – Multimedia

Chronic administration of a new therapeutic agent improves memory in a mouse model of Alzheimer’s disease with tau deposition. content piece image
Poster

Chronic administration of a new therapeutic agent improves memory in a mouse model of Alzheimer’s disease with tau deposition.

Abnormal tau hyperphosphorylation and accumulation into neuronal neurofibrillary tangles are linked to neurodegeneration in Alzheimer’s disease. The aim of this study was to test the effects of a new therapeutic agent in a mouse model of tau deposition (Tg4510 mice). Mice treated with test agent-1 showed improvements in learning and memory compared to the control mice together with a reduction in tau oligomers in hippocampi homogenates.
Resolve Your Western Blotting Woes with Better Antibodies content piece image
Video

Resolve Your Western Blotting Woes with Better Antibodies

PrecisionAb™ Validated Western Blotting Antibodies are our solution to the current pain points of many protein scientists looking for high-quality, trustworthy antibodies to detect their protein of interest with minimal optimization.
How Does an Antibody Become a PrecisionAb™ Antibody? content piece image
Video

How Does an Antibody Become a PrecisionAb™ Antibody?

For a primary antibody to be selected as a PrecisionAb Antibody, it must be highly specific, highly sensitive, and pass a rigorous validation process that includes consistent performance from batch to batch.
Western Blotting without Trial and Error- Use PrecisionAb™ Antibodies content piece image
Video

Western Blotting without Trial and Error- Use PrecisionAb™ Antibodies

Watch this video to see how PrecisionAb Validated Western Blotting Antibodies are defining a new standard of quality that you can trust to deliver superior results and reproducibility in western blotting.
PrecisionAb™ Antibodies- Enhance Your Western Blotting Toolbox content piece image
Video

PrecisionAb™ Antibodies- Enhance Your Western Blotting Toolbox

These are premium-quality antibodies extensively validated for western blotting.
Can We Trust Western Blots? content piece image
Video

Can We Trust Western Blots?

The generally low quality of western blotting data has led scientists to question whether we can trust protein quantification when using western blots.
Western Blotting content piece image
Video

Western Blotting

This video demonstrates SDS-PAGE separation of proteins using the Bio-Rad Comparative Proteomics Kit II: Western Blot Module.
Examining the Role of Arginase1 Overexpression in an Animal Model of Tauopathy content piece image
Poster

Examining the Role of Arginase1 Overexpression in an Animal Model of Tauopathy

Because of the possible beneficial role of polyamines, metabolism of arginine by arginase is of interest. Recently, our lab has recently shown that arginase1 overexpression has the ability to reduce phosphorylated tau and neurofibrillary tangles in rTg4510 and PS19 tau transgenic mice. Based on these data, we utilized the transgenic tetO MAPT*P301L mouse model to examine a potential therapeutic gene of interest, arginase1, in an animal model of tauopathy.
Disruption of Normal Circadian Function in a Mouse Model of Tauopathy content piece image
Poster

Disruption of Normal Circadian Function in a Mouse Model of Tauopathy

This study is focused on elucidating how tauopathy disrupts normal circadian clock function at both the behavioral and molecular levels.
Inecalcitol Stimulates CD38 Expression in Multiple Myeloma and Acute Myeloid Leukemia Cell Lines content piece image
Poster

Inecalcitol Stimulates CD38 Expression in Multiple Myeloma and Acute Myeloid Leukemia Cell Lines

Inecalcitol is a vitamin D receptor agonist currently in Phase II clinical trial in AML (acute myeloid leukemia). Inecalcitol increases the expression of CD38 at the surface of 5 multiple myeloma cell lines; therefore, inecalcitol could potentiate the clinical response of MM patients to a therapeutic anti-CD38 antibody
Inecalcitol induces the expression of the CD38 antigen at the surface of 4 AML cell lines; thus, inecalcitol could render AML patients sensitive to a therapeutic anti-CD38.
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