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An Innovative Approach to High Aggregate Challenges in Engineered Monoclonal Antibodies

Advances in design of engineered monoclonal antibody (MAb)–based therapeutics are generating a wide range of novel, efficacious biomolecules. However, their manufacturing can also form mis paired products, fragments and high levels of aggregation, resulting in downstream purification polishing challenges for traditional processes that result in low recoveries and poor process economics.

In this webinar, hear from a technical specialist on addressing the challenges with antibody aggregates and process related impurity removal using a new high performance chromatography resin specifically developed to address removal of high molecular weight species in flow-through mode by immobilizing a flocculant onto a rigid porous bead.

Watch this webinar to learn more about:

  • The challenges of traditional polishing steps for high aggregate mAb feedstocks
  • Analyzing data on aggregate removal and process efficiency using a novel chromatography resin 
  • How this novel resin can be used in flow through mode for expanded operating range
Al De Leon, PhD
Al De Leon, PhD
Manager, Research and Development
Thermo Fisher Scientific
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