Staphylococcus epidermidis is an ubiquitous colonizer of healthy human skin, but it is also a notorious source of serious nosocomial infections with indwelling devices and surgical procedures such as hip replacements.
It has not been known whether all members of the S. epidermidis population colonizing the skin asymptomatically are capable of causing such infections, or if some of them have a heightened tendency to do so when they enter either the bloodstream or a deep tissue.
High-risk genotypes are identified proactively
FCAI (Finnish Center for Artificial Intelligence) scientists Johan Pensar and Jukka Corander joined a team of microbiologists and geneticists to unravel this mystery. By combining large-scale population genomics and in vitro measurements of immunologically relevant features of these bacteria, they were able to use machine learning to successfully predict the risk of developing a serious, and possibly life-threatening infection from the genomic features of a bacterial isolate.
This opens the door for future technology where high-risk genotypes are identified proactively when a person is to undergo a surgical procedure, which has high potential to reduce the burden of nosocomial infections caused by S. epidermidis.
This article has been republished from materials provided by University of Helsinki. Note: material may have been edited for length and content. For further information, please contact the cited source.
Reference: Méric, G., Mageiros, L., Pensar, J., Laabei, M., Yahara, K., Pascoe, B., … Sheppard, S. K. (2018). Disease-associated genotypes of the commensal skin bacterium Staphylococcus epidermidis. Nature Communications, 9(1), 5034. https://doi.org/10.1038/s41467-018-07368-7