We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
A Systems Biology Approach is used to Investigate Chronic Lung Diseases
News

A Systems Biology Approach is used to Investigate Chronic Lung Diseases

A Systems Biology Approach is used to Investigate Chronic Lung Diseases
News

A Systems Biology Approach is used to Investigate Chronic Lung Diseases

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "A Systems Biology Approach is used to Investigate Chronic Lung Diseases"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

The team, made up of researchers from the Institute of Systems Biology in Seattle and the Battelle Memorial Institute, have developed a technique that uses a systems biology approach together with information from global data sets to identify perturbed gene networks that are associated with chronic lung disease. 

The method used lung tissue samples from patients with different types of ILD, obtained from the Lung Tissue Research Consortium. Total cell RNA was isolated and global mRNA and microRNA were profiled and the differential expression changes verified by hybridization and amplification-based methods. Differentially expressed genes were compiled and used to identify critical signaling pathways and potential biomarkers. Certain modules of genes were identified that formed a regulatory network and studies were performed on cultured cells in vitro for comparison with the in vivo results.

The paper, entitled 'Systems biology of interstitial lung diseases: integration of mRNA and microRNA expression changes' is available online through BioMed Central Medical Genomics

Advertisement