Building Protein-Protein Interaction Networks with Proteomic and Informatics Tools
News Jun 20, 2011
The systematic characterization of the whole interactomes of different model organisms has revealed that the eukaryotic proteome is highly interconnected. Therefore, biological research is progressively shifting away from classical approaches which focus only on a few proteins towards whole protein interaction networks to describe the relationship of proteins in biological processes. In this mini-review, we survey the most common methods for the systematic identification of protein interactions, and exemplify different strategies for the generation of protein interaction networks.
The article is published online in the Journal of Biological Chemistry and is free to access.
Computer bits are binary, with a value of 0 or 1. By contrast, neurons in the brain can have all kinds of different internal states, depending on the input that they received. This allows the brain to process information in a more energy-efficient manner than a computer. A new study hopes to bring the two closer together.
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