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Imaging the ORC Complex Responsible for Genome Replication

News   Sep 17, 2020 | Original story from Cold Spring Harbor Laboratory

 
Imaging the ORC Complex Responsible for Genome Replication

The Origin of Replication Complex (ORC) is a structure that binds to DNA and starts the genome duplication process as a cell gets ready to divide. In this model of human ORC, the almost donut-shaped complex clamps down on DNA (the twisted helix shown in red in the central model). The model on the left shows the complex covered, protecting the DNA binding cavity. The model on the right shows the complex open, empty of DNA. Credit: Joshua-Tor lab/CSHL, 2020.

 
 
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