Aggregators, frequent hitters, covalent-acting electrophiles, and various other artifact-generating compounds have been pre-filtered from the 'Screening' set. The removed agents can still be searched in the 'Building Blocks' set. Chemonaut has been assembled by a consortia of global compound vendors and computational chemists and features readily obtainable compounds (solids and/or stock solutions), centralized one-step compound procurement, and plate formatting service in 96-well plates or 96-tube plates. To be brief, for the first time the screening groups outside of pharma (institutes, academic screening centers, small pharma) have access to a huge high quality database and compound collection to test their hypotheses and to generate new structure-activity relationships with leadlike and druglike compounds.