Proteomics for Systems Toxicology
News Nov 24, 2014
Current toxicology studies frequently lack measurements at molecular resolution to enable a more mechanism-based and predictive toxicological assessment. Recently, a systems toxicology assessment framework has been proposed, which combines conventional toxicological assessment strategies with system-wide measurement methods and computational analysis approaches from the field of systems biology. Proteomic measurements are an integral component of this integrative strategy because protein alterations closely mirror biological effects, such as biological stress responses or global tissue alterations. Here, we provide an overview of the technical foundations and highlight select applications of proteomics for systems toxicology studies. With a focus on mass spectrometry-based proteomics, we summarize the experimental methods for quantitative proteomics and describe the computational approaches used to derive biological/mechanistic insights from these datasets. To illustrate how proteomics has been successfully employed to address mechanistic questions in toxicology, we summarized several case studies. Overall, we provide the technical and conceptual foundation for the integration of proteomic measurements in a more comprehensive systems toxicology assessment framework. We conclude that, owing to the critical importance of protein-level measurements and recent technological advances, proteomics will be an integral part of integrative systems toxicology approaches in the future.
The review is published online in Computational and Structural Biotechnology Journal and is free to access.
Chemical Topology of Silica Influences its EffectivenessNews
Researchers find that the chemical topology of silica can influence the effectiveness of many chemical processes that use it. Silica is a versatile material used in myriad industrial processes, from catalysis and filtration, to chromatography and nanofabrication.READ MORE
'Royal' Pheromone Identified in TermitesNews
Researchers have for the first time identified a specific chemical used by the higher termite castes – the queens and the kings – to communicate their royal status with worker termites. The findings could advance knowledge of termite evolution, behavior and control.READ MORE
Making Fragrances Last LongerNews
From floral perfume to fruity body wash and shampoos, scents heavily influence consumer purchases. But for most, the smell doesn’t last long after showering before it fades away. Scientists have now developed a way to get those fragrances to stick to the skin longer instead of washing down the drain immediately after being applied.READ MORE