MALDI Imaging Mass Spectrometry for the Study of Cardiovascular Pathology
Download this poster to learn how a comprehensive MALDI mass spectrometry (MALDI-IMS) approach to formalin-fixed paraffin-embedded (FFPE) tissue samples was developed to study cardiovascular pathology.
Combatting Human Trafficking Using DNA Databases Across National Boundaries
DNA Databases To Combat Human Trafficking: Addressing Technical, Legal and Diplomatic Obstacles To International Collaborations.
Computer simulation to support mammography physics education
We have designed and implemented a software tool called MX-RayCalc, that simulates mammography X-ray production and transport, to create an interactive environment to support education in either an instructor-led or self-directed environments.
Applying QbD in Process and Impurity Control Strategy Development
Manage impurity data in pharmaceutical development more effectively in a single informatics solution. Assemble all relevant analytical data with chemical information for real-time access to project information by the entire team.
Automated Parallel Derivatization Strategy with Broad Metabolite Coverage Coupled to SWATH/MS Data Acquisition for Qualitative and Quantitative Analysis
We propose a workflow including an automated fast parallel derivatization of amines, phenols, aldehydes, alcohols and ketones followed by QUAL/QUANT SWATH/MS analysis for broad metabolite coverage.
Profiling Personal Air Pollutant Exposures Using a Wearable Non-Selective Passive Wristband
Characterizing cumulative exposure to air pollutant mixtures is a critical step in understanding disease development. The Fresh Air wristband was tested as a personal exposure assessment tool with promising results.
A Computational Model of Mood and Future Prospects
Mood disorders are characterized by changes in reaction to positive events, but studies examining mood in gambling have suggested these changes may not be different from control. Interrogating mood changes with a computational model may give insight into disorders like depression.
New Biotransformation Prediction Engine Integrated into a Metabolite Identification Solution
Here we present a new prediction algorithm that determines the likelihood of biotransformation reactions, and subsequent metabolite identification, within an automated processing routine.
A New Method for Analyzing MSe/All Ions Fragmentation in Xenobiotic Metabolism Studies
During early drug discovery, the study of metabolism plays an essential role in determining which drug candidates move forward into development and later stages. As an alternative to traditional Data Dependent Acquisition (DDA), the use of MSE/All Ions Fragmentation (AIF) has become common in metabolite identification workflows for the analysis of metabolic hot spots. Here we present a solution for analysis of MSE/AlF in metID studies.
Exploiting Polypharmacology in Precision Oncology: Identification of Differential Kinase Off-targets Among Clinical PARP Inhibitors
Can we use computational methods to identify previously unknown off-targets of PARP inhibitors that can explain their observed differences?