A Computational Model of Mood and Future Prospects

Poster May 04, 2018

View Poster

Rachel Bedder, Bastien Blain, Emily Lowther, Robb Rutledge

Mood disorders are characterized by changes in reaction to positive events, but studies examining mood in gambling have suggested these changes may not be different from control. Interrogating mood changes with a computational model may give insight into disorders like depression.

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

View Poster

OTHER POSTERS

Depression, Anxiety and Apathy in Young-Onset and Atypical Dementia: A systematic review

Poster

This study aims to examine the body of empirical studies investigating the prevalence of depression, anxiety, and apathy in atypical and young-onset dementia.

Psychiatric Risk Gene Cacna1c and Early Life Stress: Potential Gene-Environment interactions?

Poster

Early life stress (ELS) is highly associated with development of psychopathology
and mood disorders in adulthood. Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders. This poster assessed the expression of Cacna1c following prepubertal stress.

Regulatory T-Cells (Tregs) Within Bone Marrow-Derived Stem Cells (BMSCs) Actively Confer Immunomodulatory and Neuroprotective Effects Against Stroke

Poster

We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.