Adaptive mixture filtering: an alternative to particle filtering?

We propose a workflow including an automated fast parallel derivatization of amines, phenols, aldehydes, alcohols and ketones followed by QUAL/QUANT SWATH/MS analysis for broad metabolite coverage.

Mood disorders are characterized by changes in reaction to positive events, but studies examining mood in gambling have suggested these changes may not be different from control. Interrogating mood changes with a computational model may give insight into disorders like depression.

Can we use computational methods to identify previously unknown off-targets of PARP inhibitors that can explain their observed differences?