Assessing Chemical-Mediated in Thyroid Function In Vitro

Poster Mar 05, 2021

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Concept Life Sciences

The hypothalamic-pituitary-thyroid axis (HPT axis) is conserved across vertebrate evolution. Perturbation of thyroid hormone homeostasis (THH) can lead to adverse effects in thyroid function affecting growth, metabolism and cognitive function. In utero, appropriate thyroid hormone concentrations are vital for normal nervous system development and a variety of experimental approaches are required to thoroughly investigate the effects of chemicals on thyroid function.

Download this poster to discover numerous in vitro approaches including:

Recombinant deiodinase inhibition
In vitro hepatic UGT mRNA expression
Thyroid peroxidase inhibition
Hepatic T4-glucuronidation analytical method
Ex vivo and in vitro T4-glucuronidation
Rat sodium iodide symporter inhibition

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

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