Combining Imaging and OMICs: MALDI Guided SpatialOMx® Probes Proteomic Mass Profiles of Breast Cancer Tumor Subpopulations
Poster Apr 02, 2020

Janina Oetjen, Romano Hebeler, Frédéric Dewez, Corinna Henkel, Benjamin Balluff, Ron Heeren
While MALDI Imaging provides a direct link between tissue pathology and molecular expression, it lacks the in-depth molecular characterization attributed to 4D-OMICS strategies. SpatialOMx, an integration of MALDI Imaging with 4D-OMICs, yields a more comprehensive understanding of biochemical activity within the tissue microenvironment.
Download this poster to discover how the SpatialOMx workflow using timsTOF fleX provides detailed in-situ characterization of bioactivity across different tumor cell subpopulations by:
- Automated segmentation of tissue microenvironment based on label-free mapping of molecular expression
- Identification and location of distinctive tissue subtypes for laser microdissection and targeted OMICS analysis
- Performing in-depth 4D-proteomics analysis of excised material using PASEF
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

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For circulating cell free DNA (ccfDNA) to be used in cancer research successfully, workflow standardization is essential. Access this poster to discover tips on optimal workflow control, how to yield smaller ccfDNA fragments and the differences in quantification and qualification of ccfDNA.
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