Combining Imaging and OMICs: MALDI Guided SpatialOMx® Probes Proteomic Mass Profiles of Breast Cancer Tumor Subpopulations

Poster Apr 02, 2020

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Janina Oetjen, Romano Hebeler, Frédéric Dewez, Corinna Henkel, Benjamin Balluff, Ron Heeren

While MALDI Imaging provides a direct link between tissue pathology and molecular expression, it lacks the in-depth molecular characterization attributed to 4D-OMICS strategies. SpatialOMx, an integration of MALDI Imaging with 4D-OMICs, yields a more comprehensive understanding of biochemical activity within the tissue microenvironment.

Download this poster to discover how the SpatialOMx workflow using timsTOF fleX provides detailed in-situ characterization of bioactivity across different tumor cell subpopulations by:

Automated segmentation of tissue microenvironment based on label-free mapping of molecular expression
Identification and location of distinctive tissue subtypes for laser microdissection and targeted OMICS analysis
Performing in-depth 4D-proteomics analysis of excised material using PASEF

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

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