Interrogation and Modulation of the Immunosuppressive Activity of Human TAM-Like Macrophages Using In Vitro Cultures
Poster Jan 13, 2021
Concept Life Sciences
The tumor microenvironment supports the development of tumor associated macrophages (TAMs) which are characterized by an immune-suppressive phenotype. TAMs can facilitate the proliferation of tumor cells and are able to suppress anti-tumor immune responses within the tumor microenvironment, making them a highly attractive target for the development of innovative cancer immunotherapies.
Download this poster to discover:
- A suite of assays that can be used to test novel compound activity
- How to select the most effective therapeutic compounds for further investigation
- Identification of the most appropriate tumor type for clinical development
For circulating cell free DNA (ccfDNA) to be used in cancer research successfully, workflow standardization is essential. Access this poster to discover tips on optimal workflow control, how to yield smaller ccfDNA fragments and the differences in quantification and qualification of ccfDNA.READ MORE
Multiplexing cell-based assays is possible using 3D culture models that are larger and more complex than monolayers
Real-time detection methods to measure live or dead cells provide much flexibility for multiplexing
All multiplexed assay combinations should be verified using appropriate controls for each 3D cell culture model.