Genedata Screener Debuts Interactive Time-Series Data Analysis

Genedata, a leading provider of advanced software solutions for drug discovery and life science research, has announced Genedata Screener® Time-Series Extension (TSE), the industry's first solution for integrated and interactive analysis of time-series data. It supports, in parallel, multiple read-outs from a range of experiments such as Calcium mobilization, Label-free, and Ion-channel assays. TSE's single-platform integration with a variety of instruments streamlines workflows and improves the efficiency of data analysis in discovery research. Additional capabilities include enhanced support for Thermal Shift assays and improved visualization of time traces.

Time-series data are acquired through instruments that use specific detection technologies such as time-resolved fluorescence, surface plasmon resonance, planar waveguides, or trans-membrane current. Traditionally, data from these technologies are analyzed with the software associated with the read-out instrument. This approach fragments the research workflow and dilutes efficiency. Genedata Screener TSE is a single platform for screening data analysis and management that directly imports time-series data from instruments. It gives researchers full control over the complete analysis from trace aggregation (data reduction to yield per well results) to secondary analysis (e.g. hit list creation or dose-response curve fitting). Acting as a central hub for analyzing such experiments, Genedata Screener TSE helps to automate repetitive steps. The following are among TSE's capabilities:
- on-the-fly correction and display of baseline-adjusted curves for improved visual comparison of traces with different baselines;
- permanent display of control medians to facilitate comparison of individual compound traces; and
- flexible annotation to support other metrics such as temperature, which is especially useful for Thermal Shift assays.

Genedata Screener TSE is a new module to the recently announced Genedata Screener version 10, which is used for Calcium mobilization (e.g. FLIPR), Label-free, and Ion-channel experiments. Designed for all plate-based screening data analysis, Genedata Screener 10 features additional extensions including: High Content Extension for high-content data integration, image access and display, feature combination, and clustering; and Cell Population Extension for interactive definition and aggregation of cell populations. These extensions are enabled by the new Genedata Screener 10 architecture, which advances the solution's flexibility and easy adaptation to customer-specific experimental settings.

"Genedata Screener helps researchers push the envelope on productivity and efficiency in plate-based screening," noted Dr. Othmar Pfannes, CEO of Genedata. "The ability to conduct data analysis on any type of time-dependent experiment from different technologies - all in one system - is unprecedented. Moreover, Genedata Screener 10 enables productivity gains and improves experiment results, which lifts the ROI for sophisticated screening technologies to new levels."