Product News Jul 09, 2008
ProtParam computes various physico-chemical properties that can be deduced from a protein sequence. No additional information is required about the protein under consideration. The protein can either be specified as a Swiss-Prot/TrEMBL accession number or ID, or in form of a raw sequence. White space and numbers are ignored. If you provide the accession number of a Swiss-Prot/TrEMBL entry, you will be prompted with an intermediary page that allows you to select the portion of the sequence on which you would like to perform the analysis. The choice includes a selection of mature chains or peptides and domains from the Swiss-Prot feature table (which can be chosen by clicking on the positions), as well as the possibility to enter start and end position in two boxes. By default (i.e. if you leave the two boxes empty) the complete sequence will be analyzed. The parameters computed by ProtParam include the molecular weight, theoretical pI, amino acid composition, atomic composition, extinction coefficient, estimated half-life, instability index, aliphatic index and grand average of hydropathicity (GRAVY).