SISCAPA Licenses Liquid Chromatography/Mass Spectrometry Assay Technology to Waters Corporation

SISCAPA Assay Technologies, Inc. (SAT), developer of precision mass spectrometry assays for protein quantitation, recently announced that Waters Corporation has obtained a nonexclusive license to certain technology from SAT for the standardization of liquid chromatography/mass spectrometry assays. 

The patent-pending technology uses multiple stable isotope-labeled versions of an analyte molecule, each with a distinct mass increment, added to a sample at different known concentrations as a way to establish a within-sample internal standard curve. Such a multi-point internal standard curve offers operational advantages such as speed of analysis and a reduction in cost and time to results as compared to external calibration (in which a set of calibrators must be run before a test sample), or internal calibration using a single stable-isotope labeled standard (“single-point” calibration).

 “We are extremely happy to enable Waters’ use of this technology, which is applicable to proteins, peptides and small molecules,” said Leigh Anderson, SAT’s CEO. “The approach could be particularly valuable in bringing mass spectrometry assays into the clinical laboratory, where calibration using a standard curve is established practice. Importantly, this approach fits well with our SISCAPA protein assay panels used to measure protein biomarkers in serum and dried blood microsamples.”

Dr. Jeff Mazzeo, V.P. of Marketing, Waters Corporation, commented: “With the licensing of SAT’s technology, we are now in the process of evaluating the benefits of the approach for quantitative LC/MS assays in a number of application areas.”