Symyx Direct Bridges the Gap Between Bioinformatics and Cheminformatics

Symyx Technologies, Inc. has released the Symyx Direct 7.0 data cartridge - a stop solution for registering, searching, and retrieving chemical and biological entities stored in relational databases.

Symyx Direct 7.0 is designed to improve R&D efficiency, project team collaboration, and IP management by enabling multidisciplinary project teams to visualize, explore, and compare novel macromolecular sequences and chemical structures stored in a single, fully searchable corporate registry system.

"Biologics now represent over 30%, and in some cases over 50%, of our customers' product pipelines," said Dr. Trevor Heritage, president, Symyx Software. "Responding to our industry's critical need for end-to-end combined biologics and chemical acquisition, registration, and management—and guided by our Biologics Advisory Board—Symyx is pleased to introduce an enhanced data cartridge that improves the management and re-use of broader, deeper IP in today's increasingly integrated chemical and biological R&D environment."

Symyx Direct 7.0 supports natural post- translational modifications (PTM) and custom modifications while also providing support for D-amino acids and complex cyclizations, including the imidazolinone fluorophore found in the fluorescent proteins.

Symyx Direct 7.0 offers a new, hybrid representation that combines features of bioinformatics and cheminformatics notations, for multidisciplinary collaborative research by enabling scientists to:

• Register and retrieve molecules, reactions, and biomolecular sequences including peptides, oligonucleotides, and oligosaccharides

• Search for and view chemical modifications in sequences

• Develop structure-activity correlations in sequences

Used by more than 80 percent of life sciences organizations worldwide, the Symyx Direct data cartridge offers proven performance with databases containing more than 30 million structures and more than 17 million reactions.