Cell Microsystems

This case study highlights a novel platform that enabled a research team to identify, isolate and expand rare NIH-3T3 clones expressing HER2 and EBFP2, achieving results in weeks rather than months.

Dr. Bastiaan Krom, Professor at the University of Amsterdam, will illustrate the power of dynamic visualization of microbial biofilms as he discusses how his laboratory has elucidated time-dependent processes in microbial biofilms.

BioFlux shear flow systems provide researchers with the power to introduce physiological and pathological shear flow, along with environmental gas and temperature control, effectively emulating in vivo conditions and revealing the cells’ true biology

This whitepaper explores the available technologies, key challenges and the growing impact of single-cell cloning.

Colossal Biosciences is bringing back extinct animal species through genetic engineering, and using advanced biotechnology methods to help preserve endangered species. This process requires a large number of precision genome edits to be made in single cells that can be isolated, grown monoclonally, expanded, and re-edited. While Colossal generates mouse models to test some of these edits, typically the cell lines cultured are non-model organisms that are poorly characterized and require extensive optimization.

In this webinar we will discuss the challenges picking gene edited mouse embryonic stem cell colonies, and difficulties isolating monoclonal cell lines from non-model organisms. We will discuss automated alternatives to flow-sorting and manual colony picking with that improve single-cell outgrowth and increase gene editing efficiency.

Reprogrammed patient-specific induced pluripotent stem cells (iPSCs) are a valuable resource in the development of models for studying unique diseases or drug responses.

Traditional organoid culture can present challenges for the downstream analysis of single organoids. In this webinar, Dr. Allysa Stern will discuss a unique workflow that enables clonal organoid development, monitoring of iPSC differentiation over time and automated isolation of single organoids.

Dr. Scott Magness will then present a case related to his group’s work investigating tumor cell heterogeneity through clonal organoid morphology and transcriptomics. He will discuss new approaches using single organoid transcriptomics to evaluate organoids derived from single cells from gastric dysplastic tissues and how this approach might reveal new ways to investigate tumor cell heterogeneity and evasion of some cells from cancer treatments.