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Informatics

Informatics

TriLink BioTechnologies

TriLink BioTechnologies, part of Maravai LifeSciences, is a best-in-class contract development and manufacturing organization (CDMO) for the synthesis of nucleic acids, nucleoside triphosphates and mRNA capping analogs. They has scale-up expertise and unique mRNA, oligonucleotide and plasmid production capabilities for companies focused on therapeutic, vaccine, diagnostic and biopharmaceutical breakthroughs.

Latest Content

3D illustration of blue and white protein structures representing enhanced protein expression through Poly(A) innovation.

App Note / Case Study

Boost Protein Expression With Poly(A) Innovation

This technical note explores a novel poly(A) tail modification that enhances total protein expression and extends expression duration across multiple constructs and cap structures, without increasing immune response.

3D molecular model of RNA double helix structure used in RNA screening research.

High Purity Guide RNA for CRISPR Screening Applications

This whitepaper highlights a ligation-based workflow that enhances gRNA purity and yield, delivering consistent performance for demanding genome editing applications.

TriLink CleanCap IVT kit with color-coded reagent vials and a branded product box on blue background with molecular graphics

CleanCap IVT Kit for High Yield Low dsRNA

Streamline your mRNA synthesis and enhance your results using TriLink’s CleanCap® AG (3’ OMe) CleanScript™ IVT Kit, which includes all necessary components to run high-yield, low-dsRNA IVT with CleanCap® co-transcriptional capping.

An application note on reducing dsRNA during mRNA synthesis using novel RNA polymerase.

App Note / Case Study

Preventing Double-Stranded RNA Formation in mRNA Manufacturing

This application note highlights how a novel RNA polymerase provides a seamless solution that reduces dsRNA formation, minimizing the need for additional purification steps while maintaining superior mRNA quality and yield.

Bioluminescent imaging of mice comparing CleanCap AG, AG 3' OMe, and M6 mRNA expression levels

App Note / Case Study

Streamlined mRNA Capping Strategies for Enhanced Therapeutic Potential

This application note explores how these cutting-edge capping strategies enhance mRNA potency, stability and expression, providing valuable insights for researchers and manufacturers.

3D rendering of a CRISPR-Cas9 enzyme editing a DNA strand, illustrating genetic engineering and molecular biology

Revolutionize mRNA Manufacturing Using a Novel RNA Polymerase

This poster explores how a novel polymerase variant provides the tools needed to reduce double-stranded RNA (dsRNA) byproducts during manufacturing, ensuring the tolerability, safety and potency of mRNA vaccines and therapeutics.

A visual zoomed in representation of a mRNA cap

The Economics of Synthetic mRNA Capping Strategies

This whitepaper evaluates the results of a study into the three main capping options available to manufacturers, highlighting expert insights on mRNA capping costs and customer needs.

An RNA strand.

TriLink BioTechnologies Collaborates With Johns Hopkins University To Establish a New RNA Innovation Center

The collaborative center will help to lower barriers to RNA innovation and discovery.

A strand of mRNA.

TriLink BioTechnologies® Announces New San Diego Facility for Late Phase mRNA Drug Substance Production

TriLink BioTechnologies (TriLink®), a Maravai LifeSciences company (NASDAQ: MRVI) has announced the grand opening of its new cGMP mRNA manufacturing facility.

A scientist holding a vial.

TriLink BioTechnologies^® Solidifies IP Position With Awarded Patents for CleanCap^® Capping Technology in China and Canada

TriLink’s CleanCap^® capping technology is patented globally & TriLink is the sole authorized manufacturer of CleanCap^® capping analogs

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