Cell Culture – News and Features

Axolotl limbs regenerate functional body parts in just weeks, relying on cells that retain positional memory. The Hand2 gene marks the posterior side of the limb and controls the activation of the Shh signaling pathway after injury.

Researchers have identified flavonoids toxic to bladder cancer cells cultured in the lab. Cell Painting technology enabled them not only to identify anticancer compounds but also to uncover insights into their mechanism of action.

Medulloblastomas are one of the most common childhood brain cancers. University of Michigan researchers have now identified a new target for Group-3 medulloblastomas. The results help identify new therapeutic avenues for treating these deadly tumors.

A study from NTNU reveals that JAK inhibitors, prescribed for autoimmune diseases like rheumatoid arthritis, may suppress the body’s antiviral defenses, making patients more vulnerable to viruses like influenza and SARS-CoV-2.

Scientists have developed an advanced gene editor – the evoCAST – that can add long stretches of DNA to defined locations in the human genome without creating unwanted modifications.

Researchers have created a groundbreaking 3D-printed artificial tumor tissue capable of replicating the in vivo conditions of patient-derived cancer cells, which can be used to predict prognosis.

Researchers have completed the full genome of the northern white rhinoceros, aiding efforts to rescue the functionally extinct species. The high-quality reference genome enables quality control of stem cells intended to create sperm and eggs.

Researchers have identified that the balance between two proteins – STAT3 and STAT5 – is important for making tumors vulnerable to immune checkpoint therapy and targeting STAT3 degradation is a potential novel cancer immunotherapy strategy.

Scientists have engineered a monoclonal antibody that can protect mice from a lethal dose of influenza A, a new study shows. The protective effect was enhanced by delivering the antibody in a nasal spray.

A new study shows AI can design synthetic DNA to precisely control gene expression in healthy mammalian cells. The model created custom enhancers from scratch, enabling selective gene activation or suppression in blood cell types.