Drug Targets – Multimedia

Researchers reveal how pancreatic cancer cells adapt to the low-energy environment of a tumor: by eating their own mitochondria! Now, by targeting this process, researchers hope to halt cancer cell proliferation.

Here, we take a closer look at some recent developments in the world of proteomics research.

Binding kinetic research is both beneficial and critical for successful drug discovery research. In this eBook, we delve into the role of binding kinetics in pharmacology, methods for measuring kinetic parameters, and applications.

Every field of biology has a moonshot vision. Whether that be identifying a new cell type in a poorly characterized tissue, finding a lasting, effective drug target for Alzheimer’s disease or reaching 100% remission rates for immunotherapy across patients and cancer types.

In this episode, the Technology Networks team reviews world-leading research into the mechanisms behind endometriosis, a condition that affects up to 10% of women of reproductive age, but often takes a decade to diagnose. There's also a peek into mom's brain during birth and a new cancer vaccine that harnesses similar technology used to create the Oxford–AstraZeneva COVID-19 vaccine.

Target identification and characterization are key challenges in drug discovery and begin with identifying the function of a possible therapeutic target and its role in the disease.

Being able to accurately predict drug–target interactions (DTIs) and drug–target binding affinity (DTBA) is crucial in early drug development and during drug repurposing endeavors. Here, we look at some recent research developments in this space.

Stem cells are increasingly being used in new and innovative ways to improve the drug discovery process – spanning academia, biotech start-ups and large pharmaceutical companies.

Drugs elicit their desired therapeutic effects by interacting with specific disease-related targets. However, to determine exactly how a drug works inside the body it is important to address key questions. What type of drug is being used? How is it being administered? What are the characteristics of the individual taking the drug?

Download this app note to discover an automated immunoprecipitation method that offers seamless integration to protein analysis, ensures high yield and reproducibility as well as delivers low nonspecific binding with significant reductions in total and hands-on time.